Two different approaches for oral administration of voriconazole loaded formulations: Electrospun fibers versus beta-cyclodextrin complexes

Basit Öğe Kaydı
dc.authorid0000-0002-3210-3747
dc.contributor.authorSiafaka, Panoraia I.
dc.contributor.authorOkur Üstündağ, Neslihan
dc.contributor.authorMone, Mariza
dc.contributor.authorGiannakopoulou, Spyridoula
dc.contributor.authorEr, Sevda
dc.contributor.authorPavlidou, Eleni
dc.contributor.authorKaravas, Evangelos
dc.contributor.authorBikiaris, Dimitrios N.
dc.date.accessioned10.07.201910:49:13
dc.date.accessioned2019-07-10T19:56:43Z
dc.date.available10.07.201910:49:13
dc.date.available2019-07-10T19:56:43Z
dc.date.issued2016
dc.departmentİstanbul Medipol Üniversitesi, Eczacılık Fakültesi, Eczacılık Teknolojisi Bölümü, Farmasötik Teknoloji Ana Bilim Dalı
dc.departmentİstanbul Medipol Üniversitesi, Eczacılık Fakültesi, Temel Eczacılık Bilimleri Bölümü, Farmasötik Mikrobiyoloji Ana Bilim Dalı
dc.descriptionWOS: 000373712800026
dc.descriptionPubMed ID: 26927072
dc.description.abstractIn this work, a comparison between two different preparation methods for the improvement of dissolution rate of an antifungal agent is presented. Poly(epsilon-caprolactone) (PCL) electrospun fibers and beta-cyclodextrin (beta-CD) complexes, which were produced via an electrospinning process and an inclusion complexation method, respectively, were addressed for the treatment of fungal infections. Voriconazole (VRCZ) drug was selected as a model drug. PCL nanofibers were characterized on the basis of morphology while phase solubility studies for beta-CDs complexes were performed. Various concentrations (5, 10, 15 and 20 wt %) of VRCZ were loaded to PCL fibers and beta-CD inclusions to study the in vitro release profile as well as in vitro antifungal activity. The results clearly indicated that all formulations showed an improved VRCZ solubility and can inhibit fungi proliferation.
dc.identifier.citationSiafaka, P. I., Okur Üstündağ, N., Mone, M., Giannakopoulou, S., Er, S., Pavlidou, E. ... Bikiaris, D. N. (2016). Two different approaches for oral administration of voriconazole loaded formulations: Electrospun fibers versus beta-cyclodextrin complexes. International Journal Of Molecular Sciences, 17(3). https://dx.doi.org/10.3390/ijms17030282
dc.identifier.doi10.3390/ijms17030282
dc.identifier.issn1422-0067
dc.identifier.issue3
dc.identifier.scopusqualityQ1
dc.identifier.urihttps://dx.doi.org/10.3390/ijms17030282
dc.identifier.urihttps://hdl.handle.net/20.500.12511/2795
dc.identifier.volume17
dc.identifier.wosqualityQ1
dc.indekslendigikaynakWeb of Science
dc.indekslendigikaynakScopus
dc.indekslendigikaynakPubMed
dc.language.isoen
dc.publisherMDPI
dc.relation.ispartofInternational Journal Of Molecular Sciencesen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanı
dc.rightsinfo:eu-repo/semantics/openAccess
dc.subjectPCL
dc.subjectFibers
dc.subjectAntifungal
dc.subjectVoriconazole Drug
dc.subjectInclusion Complexation
dc.titleTwo different approaches for oral administration of voriconazole loaded formulations: Electrospun fibers versus beta-cyclodextrin complexes
dc.typeArticle

Dosyalar

Orijinal paket
Listeleniyor 1 - 1 / 1
Küçük Resim
İsim:
Ustundag-Neslihan 2016.pdf
Boyut:
2.14 MB
Biçim:
Adobe Portable Document Format
Açıklama:
Tam Metin / Full Text
İndir

Koleksiyon

WoS İndeksli Yayınlar Koleksiyonu
Eczacılık Fakültesi Makale Koleksiyonu
PubMed İndeksli Yayınlar Koleksiyonu
Scopus İndeksli Yayınlar Koleksiyonu