Effect of topical rifamycin application on epidural fibrosis in rats

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dc.authorid0000-0003-1367-1121
dc.contributor.authorDinç, Cem
dc.contributor.authorTuncer, Cengiz
dc.contributor.authorTürkoğlu, Mehmet Erhan
dc.contributor.authorTokmak, Mehmet
dc.contributor.authorOcak, Pınar
dc.contributor.authorEr, Uyur
dc.date.accessioned10.07.201910:49:13
dc.date.accessioned2019-07-10T19:37:20Z
dc.date.available10.07.201910:49:14
dc.date.available2019-07-10T19:37:20Z
dc.date.issued2019
dc.departmentİstanbul Medipol Üniversitesi, Tıp Fakültesi, Cerrahi Tıp Bilimleri Bölümü, Beyin ve Sinir Cerrahisi Ana Bilim Dalı
dc.description.abstractObjectives: This study aims to investigate the effects of topical rifamycin SV application on epidural fibrosis formation in a rat model. Materials and methods: Between March 2015 and April 2015, a total of 20 Wistar rats were equally and randomly divided into laminectomy only group (control group) and laminectomy and rifamycin SV group (treatment group). Laminectomy was performed between L3-L5 in all rats. Surgical field was irrigated with 1 mL rifamycin SV (1 mL). After four weeks, vertebral columns of the rats were removed en bloc between the L1 and L5 levels, and epidural fibrosis and arachnoid involvement were histopathologically evaluated and graded. Results: Grade 3 epidural fibrosis formation ratio was lower in the treatment group (40%) compared to the control group (80%). However, there was no statistically significant difference between the treatment and control groups in terms of epidural fibrosis (p=0.164) and arachnoid involvement (p=0.303). Conclusion: Intraoperative rifamycin irrigation tends to reduce epidural fibrosis formation risk, although not statistically significant.
dc.identifier.citationDinç, C., Tuncer, C., Türkoğlu, M. E., Tokmak, M., Ocak, P. ve Er, U. (2019). Effect of topical rifamycin application on epidural fibrosis in rats. Turkish Journal of Physical Medicine and Rehabilitation, 65(1), 24-29. https://dx.doi.org/10.5606/tftrd.2019.2442
dc.identifier.doi10.5606/tftrd.2019.2442
dc.identifier.endpage29
dc.identifier.issn2587-0823
dc.identifier.issue1
dc.identifier.scopusqualityQ4
dc.identifier.startpage24
dc.identifier.urihttps://hdl.handle.net/20.500.12511/1381
dc.identifier.urihttps://dx.doi.org/10.5606/tftrd.2019.2442
dc.identifier.volume65
dc.identifier.wosqualityQ4
dc.indekslendigikaynakWeb of Science
dc.indekslendigikaynakScopus
dc.indekslendigikaynakTR-Dizin
dc.indekslendigikaynakPubMed
dc.language.isoen
dc.publisherTurkish Society of Physical Medicine and Rehabilitation
dc.relation.ispartofTurkish Journal of Physical Medicine and Rehabilitationen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanı
dc.rightsinfo:eu-repo/semantics/openAccess
dc.subjectEpidural Fibrosis
dc.subjectLaminectomy
dc.subjectRifamycin
dc.titleEffect of topical rifamycin application on epidural fibrosis in rats
dc.typeArticle

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