EEG measures for clinical research in major vascular cognitive impairment: recommendations by an expert panel

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dc.authorid0000-0002-0860-0524
dc.contributor.authorBabiloni, Claudio C.
dc.contributor.authorArakaki, Xianghong
dc.contributor.authorBonanni, Laura
dc.contributor.authorBuján, Ana
dc.contributor.authorCarrillo, María C.
dc.contributor.authordel Percio, Claudio
dc.contributor.authorEdelmayer, Rebecca M.
dc.contributor.authorEgan, Gary
dc.contributor.authorElahh, Fanny M.
dc.contributor.authorEvans, Alan Charles
dc.contributor.authorFerri, Raffaele
dc.contributor.authorFrisoni, Glovannl B.
dc.contributor.authorGüntekin, Bahar
dc.contributor.authorHainsworth, Atticus Henry
dc.contributor.authorHampel, Harald
dc.contributor.authorJeli?, Vesna
dc.contributor.authorJeong, Jaeseung
dc.contributor.authorKim, Doh-kwan
dc.contributor.authorKramberger, Milica Gregori?
dc.contributor.authorKumar, Sanjeev
dc.contributor.authorLizio, Roberta
dc.contributor.authorNobili, Flavio Mariano
dc.contributor.authorNoce, Giuseppe
dc.contributor.authorPuce, Aina
dc.contributor.authorRitter, Petra
dc.contributor.authorSmit, Dirk J.A.
dc.contributor.authorSoricelli, Andrea
dc.contributor.authorTeipel, S.
dc.contributor.authorTucci, Federico
dc.date.accessioned2021-04-16T07:28:35Z
dc.date.available2021-04-16T07:28:35Z
dc.date.issued2021
dc.departmentİstanbul Medipol Üniversitesi, Rektörlük, Rejeneratif ve Restoratif Tıp Araştırmaları Merkezi (REMER)
dc.departmentİstanbul Medipol Üniversitesi, Tıp Fakültesi, Temel Tıp Bilimleri Bölümü, Biyofizik Ana Bilim Dalı
dc.description.abstractVascular contribution to cognitive impairment (VCI) and dementia is related to etiologies that may affect the neurophysiological mechanisms regulating brain arousal and generating electroencephalographic (EEG) activity. A multidisciplinary expert panel reviewed the clinical literature and reached consensus about the EEG measures consistently found as abnormal in VCI patients with dementia. As compared to cognitively unimpaired individuals, those VCI patients showed (1) smaller amplitude of resting state alpha (8–12 Hz) rhythms dominant in posterior regions; (2) widespread increases in amplitude of delta (< 4 Hz) and theta (4–8 Hz) rhythms; and (3) delayed N200/P300 peak latencies in averaged event-related potentials, especially during the detection of auditory rare target stimuli requiring participants’ responses in “oddball” paradigms. The expert panel formulated the following recommendations: (1) the above EEG measures are not specific for VCI and should not be used for its diagnosis; (2) they may be considered as “neural synchronization” biomarkers to enlighten the relationships between features of the VCI-related cerebrovascular lesions and abnormalities in neurophysiological brain mechanisms; and (3) they may be tested in future clinical trials as prognostic biomarkers and endpoints of interventions aimed at normalizing background brain excitability and vigilance in wakefulness.
dc.description.sponsorshipEuropean Commission ; Deutsche Forschungsgemeinschaften_US
dc.identifier.citationBabiloni, C. C., Arakaki, X., Bonanni, L., Buján, A., Carrillo, M. C., del Percio, C. ... Tucci, F. (2021). EEG measures for clinical research in major vascular cognitive impairment: recommendations by an expert panel. Neurobiology of Aging, 103, 78-97. https://dx.doi.org/10.1016/j.neurobiolaging.2021.03.003
dc.identifier.doi10.1016/j.neurobiolaging.2021.03.003
dc.identifier.endpage97
dc.identifier.issn0197-4580
dc.identifier.issn1558-1497
dc.identifier.scopusqualityQ1
dc.identifier.startpage78
dc.identifier.urihttps://dx.doi.org/10.1016/j.neurobiolaging.2021.03.003
dc.identifier.urihttps://hdl.handle.net/20.500.12511/6733
dc.identifier.volume103
dc.identifier.wosqualityQ2
dc.indekslendigikaynakWeb of Science
dc.indekslendigikaynakScopus
dc.indekslendigikaynakPubMed
dc.language.isoen
dc.publisherElsevier Inc.
dc.relation.ispartofNeurobiology of Agingen_US
dc.relation.publicationcategoryDiğer
dc.rightsinfo:eu-repo/semantics/embargoedAccess
dc.subjectCerebrovascular Disease (CVD)
dc.subjectEvent-Related Oscillations (EROs)
dc.subjectEvent-Related Potentials (ERPs)
dc.subjectResting State Electroencephalographic (rsEEG) Rhythms
dc.subjectSmall Vessel Disease
dc.subjectSubcortical Ischemic Vascular Disease
dc.subjectVascular Cognitive Impairment (VCI)
dc.subjectVascular Contribution to Cognitive Impairment and Dementia (VCID)
dc.subjectVascular Dementia (VaD)
dc.titleEEG measures for clinical research in major vascular cognitive impairment: recommendations by an expert panel
dc.typeReview Article

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