Mechanism of antinociceptive action of syringic acid
| dc.contributor.author | Okur, Mehmet Evren | |
| dc.contributor.author | Şakul, Ayşe Arzu | |
| dc.date.accessioned | 2021-06-10T07:52:40Z | |
| dc.date.available | 2021-06-10T07:52:40Z | |
| dc.date.issued | 2021 | |
| dc.department | İstanbul Medipol Üniversitesi, Tıp Fakültesi, Dahili Tıp Bilimleri Bölümü, Tıbbi Farmakoloji Ana Bilim Dalı | |
| dc.description.abstract | Syringic acid presents various biological properties such as antioxidant, anti-inflammatory, anticancer, and other activities. The present experiment aimed to investigate the effect of the oral administration of syringic acid (10, 50, and 100 mg/kg) on its possible nociceptive response using hot-plate and tail-flick assay in the Balb-C mice model. The mice were pre-treated with 5 mg/kg atropine 15 min before, 1mg/kg mecamylamine 20 min before, 1mg/kg ketanserin 30 min before, 1 mg/kg ondansetron 30 min before, 1mg/kg yohimbine 30 min before, 1 mg/kg prazosin 30 min before and 5 mg/kg naloxone 15min before the administration of the Syringic acid. Dose-dependent antinociceptive activity of syringic acid was reported for 50 and 100 mg/kg doses in tail-flick and hot-plate assays, respectively. In further, mecamylamine, yohimbine, and naloxone significantly reversed syringic acid-induced response to thermal stimuli in tail-flick and hot-plate assays, respectively. From the data, it was confirmed that syringic acid presents central antinociceptive effects which may be coordinated by supraspinal/spinal mediated cholinergic, opioidergic, and adrenergic, inflection. | |
| dc.identifier.citation | Okur, M. E. ve Şakul, A. A. (2021). Mechanism of antinociceptive action of syringic acid. Journal of Research in Pharmacy, 25(3), 277-286. https://dx.doi.org/10.29228/jrp.18 | |
| dc.identifier.doi | 10.29228/jrp.18 | |
| dc.identifier.endpage | 286 | |
| dc.identifier.issn | 2630-6344 | |
| dc.identifier.issue | 3 | |
| dc.identifier.scopusquality | Q3 | |
| dc.identifier.startpage | 277 | |
| dc.identifier.uri | https://dx.doi.org/10.29228/jrp.18 | |
| dc.identifier.uri | https://hdl.handle.net/20.500.12511/7121 | |
| dc.identifier.volume | 25 | |
| dc.identifier.wosquality | N/A | |
| dc.indekslendigikaynak | Web of Science | |
| dc.indekslendigikaynak | Scopus | |
| dc.indekslendigikaynak | TR-Dizin | |
| dc.language.iso | en | |
| dc.publisher | Marmara University | |
| dc.relation.ispartof | Journal of Research in Pharmacy | en_US |
| dc.relation.publicationcategory | Makale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanı | |
| dc.rights | info:eu-repo/semantics/openAccess | |
| dc.subject | Antinociception | |
| dc.subject | Muscarinic Receptors | |
| dc.subject | Opioidergic Receptors | |
| dc.subject | Alpha(2)-Adrenoceptors | |
| dc.subject | Syringic Acid | |
| dc.title | Mechanism of antinociceptive action of syringic acid | |
| dc.type | Article |
