Circadian dysfunction in adipose tissue: Chronotherapy in metabolic diseases

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dc.authorid0000-0002-1734-8340
dc.contributor.authorCivelek, Erkan
dc.contributor.authorÖztürk Civelek, Dilek
dc.contributor.authorAkyel, Yasemin Kübra
dc.contributor.authorKaleli Durman, Deniz
dc.contributor.authorOkyar, Alper
dc.date.accessioned2023-09-11T12:07:41Z
dc.date.available2023-09-11T12:07:41Z
dc.date.issued2023
dc.departmentİstanbul Medipol Üniversitesi, Tıp Fakültesi, Dahili Tıp Bilimleri Bölümü, Tıbbi Farmakoloji Ana Bilim Dalı
dc.description.abstractEssential for survival and reproduction, the circadian timing system (CTS) regulates adaptation to cyclical changes such as the light/dark cycle, temperature change, and food availability. The regulation of energy homeostasis possesses rhythmic properties that correspond to constantly fluctuating needs for energy production and consumption. Adipose tissue is mainly responsible for energy storage and, thus, operates as one of the principal components of energy homeostasis regulation. In accordance with its roles in energy homeostasis, alterations in adipose tissue's physiological processes are associated with numerous pathologies, such as obesity and type 2 diabetes. These alterations also include changes in circadian rhythm. In the current review, we aim to summarize the current knowledge regarding the circadian rhythmicity of adipogenesis, lipolysis, adipokine secretion, browning, and non-shivering thermogenesis in adipose tissue and to evaluate possible links between those alterations and metabolic diseases. Based on this evaluation, potential therapeutic approaches, as well as clock genes as potential therapeutic targets, are also discussed in the context of chronotherapy.
dc.identifier.citationCivelek, E., Öztürk Civelek, D., Akyel, Y. K., Kaleli Durman, D. ve Okyar, A. (2023). Circadian dysfunction in adipose tissue: Chronotherapy in metabolic diseases. Biology, 12(8). https://dx.doi.org/10.3390/biology12081077
dc.identifier.doi10.3390/biology12081077
dc.identifier.issn2079-7737
dc.identifier.issue8
dc.identifier.pmid37626963
dc.identifier.scopus2-s2.0-85169129266
dc.identifier.scopusqualityN/A
dc.identifier.urihttps://dx.doi.org/10.3390/biology12081077
dc.identifier.urihttps://hdl.handle.net/20.500.12511/11406
dc.identifier.volume12
dc.identifier.wos001057267200001en_US
dc.identifier.wosqualityQ2
dc.indekslendigikaynakWeb of Science
dc.indekslendigikaynakScopus
dc.indekslendigikaynakPubMed
dc.institutionauthorAkyel, Yasemin Kübra
dc.language.isoen
dc.publisherMDPI
dc.relation.ispartofBiologyen_US
dc.relation.publicationcategoryDiğer
dc.rightsAttribution 4.0 International*
dc.rightsinfo:eu-repo/semantics/openAccess
dc.rights.urihttps://creativecommons.org/licenses/by/4.0/*
dc.subjectAdipose Tissue
dc.subjectChronotherapy
dc.subjectCircadian Dysfunction
dc.subjectDiabetes
dc.subjectMetabolic Diseases
dc.subjectObesity
dc.titleCircadian dysfunction in adipose tissue: Chronotherapy in metabolic diseases
dc.typeReview Article

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