Hemostatic activity of cistus creticus extract in wistar albino rats
| dc.authorid | 0000-0002-3412-0807 | |
| dc.authorid | 0000-0001-7277-920X | |
| dc.authorid | 0000-0003-2533-5141 | |
| dc.contributor.author | Karadağ, Ayşe Esra | |
| dc.contributor.author | Çaşkurlu, Ayşegül | |
| dc.contributor.author | Okur, Mehmet Evren | |
| dc.contributor.author | Güzelmeriç, Etil | |
| dc.contributor.author | Üstündağ Okur, Neslihan | |
| dc.contributor.author | Tosun, Fatma | |
| dc.contributor.author | Yeşilada, Erdem | |
| dc.contributor.author | Demirci, Fatih | |
| dc.date.accessioned | 2021-04-12T11:26:47Z | |
| dc.date.available | 2021-04-12T11:26:47Z | |
| dc.date.issued | 2020 | |
| dc.department | İstanbul Medipol Üniversitesi, Eczacılık Fakültesi, Eczacılık Meslek Bilimleri Bölümü, Farmakognozi Ana Bilim Dalı | |
| dc.description.abstract | Aerial part preparations of Cistus creticus L., Cistaceae, are traditionally used in Anatolia as a hemostatic agent. The air-dried aerial parts were extracted with methanol. Gels were prepared, followed by the hemostatic activity evaluation using Wistar albino rats in vivo tail tip amputation model. The chemical characterization of the total extract was performed by high-performance thin-layer chromatography. The methanol extract was loaded to a hydrogel base to complete a concentration of 2.5 and 7.5%. As a result, the 2.5% extract gel was found more effective on both bleeding time and amount. Hyperoside and tiliroside, which may be the components responsible for the hemostatic properties of the analyzed plant material, were dereplicated as major constituents. | |
| dc.identifier.citation | Karadağ, A. E., Çaşkurlu, A., Okur, M. E., Güzelmeriç, E., Üstündağ Okur, N., Tosun, F. ... Demirci, F. (2020). Hemostatic activity of cistus creticus extract in wistar albino rats. Revista Brasileira de Farmacognosia, 30(6), 844-847. https://dx.doi.org/10.1007/s43450-020-00120-7 | |
| dc.identifier.doi | 10.1007/s43450-020-00120-7 | |
| dc.identifier.endpage | 847 | |
| dc.identifier.issn | 1981-528X | |
| dc.identifier.issn | 0102-695X | |
| dc.identifier.issue | 6 | |
| dc.identifier.scopusquality | Q2 | |
| dc.identifier.startpage | 844 | |
| dc.identifier.uri | https://dx.doi.org/10.1007/s43450-020-00120-7 | |
| dc.identifier.uri | https://hdl.handle.net/20.500.12511/6722 | |
| dc.identifier.volume | 30 | |
| dc.identifier.wosquality | Q4 | |
| dc.indekslendigikaynak | Web of Science | |
| dc.indekslendigikaynak | Scopus | |
| dc.language.iso | en | |
| dc.publisher | Springer Nature | |
| dc.relation.ispartof | Revista Brasileira de Farmacognosia | en_US |
| dc.relation.publicationcategory | Makale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanı | |
| dc.relation.tubitak | info:eu-repo/grantAgreement/TUBITAK/SOBAG/1139B411801272 | |
| dc.rights | info:eu-repo/semantics/openAccess | |
| dc.subject | HPTLC | |
| dc.subject | Topical Application | |
| dc.subject | Blood Stopper | |
| dc.subject | Coagulating Activity | |
| dc.subject | Flavonoid Glycoside | |
| dc.subject | Tail Bleeding | |
| dc.title | Hemostatic activity of cistus creticus extract in wistar albino rats | |
| dc.type | Article |
