Steam bath, vibration, and thermal ablation administrations augment the release of tramadol HCl from transdermal patch and enhance the plasma concentration in rats

Basit Öğe Kaydı
dc.authorid0000-0002-5532-2395
dc.contributor.authorMacit, Çağlar
dc.contributor.authorDuman, Gülengül
dc.contributor.authorMacit, Meltem
dc.date.accessioned2023-10-10T06:53:00Z
dc.date.available2023-10-10T06:53:00Z
dc.date.issued2023
dc.departmentİstanbul Medipol Üniversitesi, Eczacılık Fakültesi, Eczacılık Meslek Bilimleri Bölümü, Farmakoloji Ana Bilim Dalı
dc.description.abstractRecently, transdermal drug delivery has become popular due to their numerous advantages. They offer non-invasive application and eliminate the first-pass metabolism. The skin membrane is sensitive to heat and vibration that these applications enhance the skin permeability resulting in increased bioavailability. This study aims to determine the effect of steam bath (STB), vibration (VIB) and thermal ablation (THAB) on systemic absorption of tramadol HCl and compare all applications with each other. After preparing of tramadol HCl patches, in vitro release tests followed by in vivo animal experiments were conducted. The patches were applied to 32 Wistar albino rats divided into four groups: No potential trigger effect (NPTE), STB, VIB, and THAB. STB, VIB and THAB were applied by purchased devices. One hour later, the patches were removed and plasma concentration of tramadol HCl was measured by UV-Vis spectrophotometry at 271 nm. When compared to the control group, calculated plasma tramadol HCl µg/mL concentration increased significantly in STB, VIB and THAB (p<0.001). Finally, as trigger effects, steam bath, vibration and thermal ablation (42°C) dramatically increased the absorption amount of tramadol HCl (42.1%, 37.2 % and 43.8 %, respectively). The percentage release of tramadol HCl increased significantly in investigation groups when compared to NPTE (p[removed]
dc.description.sponsorshipDepartment of Biomedical Engineering ; Yeditepe Universityen_US
dc.identifier.citationMacit, Ç., Duman, G. ve Macit, M. (2023). Steam bath, vibration, and thermal ablation administrations augment the release of tramadol HCl from transdermal patch and enhance the plasma concentration in rats. Journal of Research in Pharmacy, 27(5), 2171-2181. https://doi.org/10.29228/jrp.496
dc.identifier.doi10.29228/jrp.496
dc.identifier.endpage2181
dc.identifier.issn2630-6344
dc.identifier.issue5
dc.identifier.scopus2-s2.0-85172459145
dc.identifier.scopusqualityQ3
dc.identifier.startpage2171
dc.identifier.urihttps://doi.org/10.29228/jrp.496
dc.identifier.urihttps://hdl.handle.net/20.500.12511/11543
dc.identifier.volume27
dc.identifier.wos001083473300006en_US
dc.identifier.wosqualityN/A
dc.indekslendigikaynakWeb of Science
dc.indekslendigikaynakScopus
dc.institutionauthorMacit, Çağlar
dc.language.isoen
dc.publisherMarmara University
dc.relation.ispartofJournal of Research in Pharmacyen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanı
dc.rightsinfo:eu-repo/semantics/openAccess
dc.subjectSteam Bath
dc.subjectThermal Ablation
dc.subjectTramadol HCl
dc.subjectTransdermal Patch
dc.subjectVibration
dc.titleSteam bath, vibration, and thermal ablation administrations augment the release of tramadol HCl from transdermal patch and enhance the plasma concentration in rats
dc.typeArticle

Dosyalar

Orijinal paket
Listeleniyor 1 - 1 / 1
Küçük Resim
İsim:
Maciit-Caglar-2023.pdf
Boyut:
734.23 KB
Biçim:
Adobe Portable Document Format
Açıklama:
Tam Metin / Full Text
İndir
Lisans paketi
Listeleniyor 1 - 1 / 1
Küçük Resim Yok
İsim:
license.txt
Boyut:
1.44 KB
Biçim:
Item-specific license agreed upon to submission
Açıklama:
İndir

Koleksiyon

Eczacılık Fakültesi Makale Koleksiyonu
Scopus İndeksli Yayınlar Koleksiyonu
WoS İndeksli Yayınlar Koleksiyonu