Novel benzothiazole based imidazole derivatives as new cytotoxic agents against glioma (C6) and liver (HepG2) cancer cell lines

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dc.authorid0000-0002-2289-7950
dc.authorid0000-0002-0841-1299
dc.contributor.authorYurttaş, Leyla
dc.contributor.authorErtaş, Merve
dc.contributor.authorAkalın Çiftçi, Gülşen
dc.contributor.authorTemel, Halide Edip
dc.contributor.authorDemirayak, Şeref
dc.date.accessioned10.07.201910:49:13
dc.date.accessioned2019-07-10T19:36:15Z
dc.date.available10.07.201910:49:14
dc.date.available2019-07-10T19:36:15Z
dc.date.issued2017
dc.departmentİstanbul Medipol Üniversitesi, Eczacılık Fakültesi, Eczacılık Meslek Bilimleri Bölümü, Farmasötik Kimya Ana Bilim Dalı
dc.description.abstractIn this work, some novel N-(6-substituted-benzothiazol-2-yl)-2-[[4,5-dimethyl-1-((p-tolyl/4-nitrophenyl)amino)-1H-imidazol-2-yl]thio]acetamide derivatives were synthesized and searched for their cytotoxic activities against C6 and HepG2 tumor cells. Among all compounds, the most active compound was determined as compound 7. It was calculated IC50 value about 15.67 µg/mL through C6 tumor cell lines and also compound 2, 4, 5, 6 were observed as good cytotoxic agents against HepG2 tumor cells. Findings about antiproliferative activity studies have encouraged the acquirement of new similar compounds in undergoing studies.
dc.identifier.citationYurttaş, L., Ertaş, M., Akalın Çiftçi, G., Temel, H. E. ve Demirayak, Ş. (2017). Novel benzothiazole based imidazole derivatives as new cytotoxic agents against glioma (C6) and liver (HepG2) cancer cell lines. Acta Pharmaceutica Sciencia, 55(1), 39-47. https://dx.doi.org/10.23893/1307-2080.APS.0553
dc.identifier.doi10.23893/1307-2080.APS.0553
dc.identifier.endpage47
dc.identifier.issn1307-2080
dc.identifier.issue1
dc.identifier.scopusqualityQ4
dc.identifier.startpage39
dc.identifier.urihttps://hdl.handle.net/20.500.12511/1106
dc.identifier.urihttps://dx.doi.org/10.23893/1307-2080.APS.0553
dc.identifier.volume55
dc.indekslendigikaynakScopus
dc.language.isoen
dc.publisherUniversity of Istanbul
dc.relation.ispartofActa Pharmaceutica Scienciaen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanı
dc.rightsinfo:eu-repo/semantics/openAccess
dc.subjectAntiproliferative Activity
dc.subjectBenzothiazole
dc.subjectCytotoxicity
dc.subjectImidazole
dc.titleNovel benzothiazole based imidazole derivatives as new cytotoxic agents against glioma (C6) and liver (HepG2) cancer cell lines
dc.typeArticle

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