The impact of hybrid capture-based comprehensive genomic profiling on treatment strategies in patients with solid tumors

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dc.authorid0000-0002-0443-6966
dc.contributor.authorDişel, Umut
dc.contributor.authorKöse, Fatih
dc.contributor.authorBilici, Ahmet
dc.contributor.authorÖzgüroğlu, Mustafa
dc.contributor.authorSağlam, Sezer
dc.contributor.authorŞeker, Mesut
dc.contributor.authorAksoy, Sercan
dc.contributor.authorTek, İbrahim
dc.contributor.authorMandel, Nil Molinas
dc.contributor.authorDemir, Gökhan
dc.contributor.authorArslan, Çağatay
dc.contributor.authorDemiray, Mutlu
dc.contributor.authorÖztürk, Mehmet Akif
dc.contributor.authorSalepçi, Taflan
dc.contributor.authorEralp, Yeşim
dc.contributor.authorSelçukbiricik, Fatih
dc.contributor.authorTemizaş, Gökçe
dc.contributor.authorFidan, Ebru Gül
dc.date.accessioned2022-09-15T12:16:01Z
dc.date.available2022-09-15T12:16:01Z
dc.date.issued2022
dc.departmentİstanbul Medipol Üniversitesi, Tıp Fakültesi, Dahili Tıp Bilimleri Bölümü, İç Hastalıkları Ana Bilim Dalı
dc.description.abstractObjective: The development of bioinformatics and comprehensive genomic profiling (CGP) has provided insights into the ap-plicability and functionality of the genomic alterations (GA). In this study, we evaluated the impact of CGP on the treatment plan and outcomes in a significant number of patients. Material and Methods: We carried out a retrospective case-control study on 164 adult patients with advanced solid tumors from 15 oncology centers in Türkiye. Results: In all cases, CGP was performed within 23.8 [standard deviation (SD)±32.1] months of initial diagnosis. Non-small cell lung carcinoma, breast cancer, unknown primary carcinoma, colorectal carcinoma, and sarcoma were among the most common tumor types, accounting for 61.5% of all cases. CGP was performed immediately after the diagnosis of advanced cancer in 13 patients (7.9%). In 158 patients (96.4%), at least one GA was found as per the CGP report. Also, in the reports, the average tumor mutational burden (TMB) and GAs were 7.3 (SD±8.7) mut/Mb and 3.5 (SD±2.0), respectively. According to CGP reports, 58 patients had 79 evidence-based drug suggestions for their particular tumor type, whereas 97 patients had 153 evidence-based drug suggestions for another tumor type. After the primary oncologist interpreted the CGP reports, significant changes were made to the treatment of 35 (21.3%) patients. Conclusion: We strongly believe that in the future, high-TMB or other tumor-agnostic biomarkers will become much more afford-able, and CGP will serve as one of the major decision-making tools for the treatment of patients along with pathological, radiological or lab-oratory tests.
dc.identifier.citationDişel, U., Köse, F., Bilici, A., Özgüroğlu, M., Sağlam, S., Şeker, M. ... Fidan, E. G. (2022). The impact of hybrid capture-based comprehensive genomic profiling on treatment strategies in patients with solid tumors. Journal of Oncological Science, 8(2), 87-93. https://doi.org/10.37047/jos.2022-89310
dc.identifier.doi10.37047/jos.2022-89310
dc.identifier.endpage93
dc.identifier.issn2651-4532
dc.identifier.issn2452-3364
dc.identifier.issue2
dc.identifier.scopus2-s2.0-85136777670
dc.identifier.scopusqualityQ4
dc.identifier.startpage87
dc.identifier.urihttps://doi.org/10.37047/jos.2022-89310
dc.identifier.urihttps://hdl.handle.net/20.500.12511/9715
dc.identifier.volume8
dc.indekslendigikaynakScopus
dc.indekslendigikaynakTR-Dizin
dc.institutionauthorBilici, Ahmet
dc.language.isoen
dc.publisherTurkiye Klinikleri
dc.relation.ispartofJournal of Oncological Scienceen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanı
dc.rightsAttribution-NonCommercial-NoDerivatives 4.0 International*
dc.rightsinfo:eu-repo/semantics/openAccess
dc.rights.urihttps://creativecommons.org/licenses/by-nc-nd/4.0/*
dc.subjectComprehensive Genomic Hybridization
dc.subjectGenomics
dc.subjectNeoplasms
dc.subjectRetrospective Studies
dc.titleThe impact of hybrid capture-based comprehensive genomic profiling on treatment strategies in patients with solid tumors
dc.typeArticle

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