Hemodynamics of neonatal double lumen cannula malposition

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dc.authorid0000-0001-5485-5440
dc.contributor.authorJamil, Muhammad
dc.contributor.authorRezaeimoghaddam, Mohammad
dc.contributor.authorÇakmak, Bilgesu
dc.contributor.authorYıldız, Yahya
dc.contributor.authorRasooli, Reza
dc.contributor.authorPekkan, Kerem
dc.contributor.authorSalihoğlu, Ece
dc.date.accessioned2020-02-26T11:07:23Z
dc.date.available2020-02-26T11:07:23Z
dc.date.issued2020
dc.departmentİstanbul Medipol Üniversitesi, Tıp Fakültesi, Cerrahi Tıp Bilimleri Bölümü, Anesteziyoloji ve Reanimasyon Ana Bilim Dalı
dc.descriptionThe author(s) disclosed receipt of the following financial support for the research, authorship, and/or publication of this article: This study was supported by European Union FP7 CIG-293931- CardioFluidMechanics, TUBITAK 118M369, and TUBITAK 1003 program grants 115E690 and 115E691 (Principle Investigators: Kerem Pekkan and Ece Salihoglu).
dc.description.abstractObjective: Malposition of dual lumen cannula is a frequent and challenging complication in neonates and plays a significant role in shaping the in vitro device hemodynamics. This study aims to analyze the effect of the dual lumen cannula malposition on right-atrial hemodynamics in neonatal patients using an experimentally validated computational fluid dynamics model. Methods: A computer model was developed for clinically approved dual lumen cannula (13Fr Origen Biomedical, Austin, Texas, USA) oriented inside the atrium of a 3-kg neonate with normal venous return. Atrial hemodynamics and dual lumen cannula malposition were systematically simulated for two rotations (antero-atrial and atrio-septal) and four translations (two intravascular movements along inferior vena cava and two dislodged configurations in the atrium). A multi-domain compartmentalized mesh was prepared to allow the site-specific evaluation of important hemodynamic parameters. Transport of each blood stream, blood damage levels, and recirculation times are quantified and compared to dual lumen cannula in proper position. Results: High recirculation levels (39 ± 4%) in malpositioned cases resulted in poor oxygen saturation where maximum recirculation of up to 42% was observed. Apparently, Origen dual lumen cannula showed poor inferior vena cava blood–capturing efficiency (48 ± 8%) but high superior vena cava blood–capturing efficiency (86 ± 10%). Dual lumen cannula malposition resulted in corresponding changes in residence time (1.7 ± 0.5 seconds through the tricuspid). No significant differences in blood damage were observed among the simulated cases compared to normal orientation. Compared to the correct dual lumen cannula position, both rotational and translational displacements of the dual lumen cannula resulted in significant hemodynamic differences. Conclusion: Rotational or translational movement of dual lumen cannula is the determining factor for atrial hemodynamics, venous capturing efficiency, blood residence time, and oxygenated blood delivery. Results obtained through computational fluid dynamics methodology can provide valuable foresight in assessing the performance of the dual lumen cannula in patient-specific configurations.
dc.description.sponsorshipEuropean Union Türkiye Bilimsel ve Teknolojik Araştırma Kurumu (TÜBİTAK)en_US
dc.identifier.citationJamil, M., Rezaeimoghaddam, M., Çakmak, B., Yıldız, Y., Rasooli, R., Pekkan, K. ... Salihoğlu, E. (2020). Hemodynamics of neonatal double lumen cannula malposition. Perfusion-uk, 35(4), 306-315. http://doi.org/10.1177/0267659119874697
dc.identifier.doi10.1177/0267659119874697
dc.identifier.endpage315
dc.identifier.issn0267-6591
dc.identifier.issue4
dc.identifier.scopusqualityQ1
dc.identifier.startpage306
dc.identifier.urihttp://doi.org/10.1177/0267659119874697
dc.identifier.urihttps://hdl.handle.net/20.500.12511/4956
dc.identifier.volume35
dc.identifier.wosqualityQ4
dc.indekslendigikaynakWeb of Science
dc.indekslendigikaynakScopus
dc.indekslendigikaynakPubMed
dc.language.isoen
dc.publisherSAGE Publications Ltd.
dc.relation.ecinfo:eu-repo/grantAgreement/EC/FP7/115E691
dc.relation.ispartofPerfusion-uken_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanı
dc.relation.tubitakinfo:eu-repo/grantAgreement/TUBITAK/SOBAG/115E690
dc.relation.tubitakinfo:eu-repo/grantAgreement/TUBITAK/SOBAG/115E691
dc.rightsinfo:eu-repo/semantics/embargoedAccess
dc.subjectExtracorporeal Membrane Oxygenation
dc.subjectDouble Lumen Neonatal Cannula
dc.subjectBlood Residence Time
dc.subjectHemolysis Index
dc.subjectOxygen Saturation
dc.subjectComputational Fluid Dynamics
dc.titleHemodynamics of neonatal double lumen cannula malposition
dc.typeArticle

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