Epidemiology of nosocomial candidemia, mortality, and antifungal resistance: 7-year experience in Turkey

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dc.authorid0000-0001-8930-741X
dc.authorid0000-0001-8022-7325
dc.authorid0000-0001-9658-7560
dc.authorid0000-0003-3952-1914
dc.authorid0000-0002-2623-7212
dc.authorid0000-0001-8945-2385
dc.contributor.authorAydın, Selda
dc.contributor.authorDerin, Okan
dc.contributor.authorŞahin, Meyha
dc.contributor.authorDinleyici, Rümeysa
dc.contributor.authorYılmaz, Mesut
dc.contributor.authorCeylan, Bahadır
dc.contributor.authorİstanbullu Tosun, Ayşe
dc.contributor.authorÖztürk, Recep
dc.contributor.authorMert, Ali
dc.date.accessioned2022-12-05T08:35:36Z
dc.date.available2022-12-05T08:35:36Z
dc.date.issued2022
dc.departmentİstanbul Medipol Üniversitesi, Tıp Fakültesi, Dahili Tıp Bilimleri Bölümü, Enfeksiyon Hastalıkları ve Klinik Mikrobiyoloji Ana Bilim Dalı
dc.departmentİstanbul Medipol Üniversitesi, Tıp Fakültesi, Temel Tıp Bilimleri Bölümü, Tıbbi Mikrobiyoloji Ana Bilim Dalı
dc.departmentİstanbul Medipol Üniversitesi, Tıp Fakültesi, Dahili Tıp Bilimleri Bölümü, İç Hastalıkları Ana Bilim Dalı
dc.departmentİstanbul Medipol Üniversitesi, Eczacılık Fakültesi, Eczacılık Meslek Bilimleri Bölümü, Klinik Eczacılık Ana Bilim Dalı
dc.description.abstractCandidemia is an important clinical condition that prolongs hospital stays and increases morbidity, mortality, and hospital costs. The aim of this retrospective study was to evaluate the epidemiological and microbiological characteristics of patients with candidemia between January 2013 and December 2019. Two hundred forty-one episodes of candidemia were observed in 230 patients, 45% of whom were female. The median age was 63 years, and 53.9% of the episodes were in the intensive care unit (ICU). Commonly observed predisposing factors for candidemia included antibiotic use (71.3%), urinary catheterization (56.3%), central venous catheter placement (50.3%), total parenteral nutrition (47.9%), solid-organ malignancy (46%), surgery (48.6%), chemotherapy (37%), and steroid treatment (25.5%). The crude mortality rate was 52.7%. A significant difference was found between survivors and non-survivors (P = 0.007) according to the Charlson Comorbidity Index. However, no statistically significant association was found between mortality and age, sex, surgical procedure, catheter-related candidemia, or Candida spp. infection. The most frequently isolated Candida sp. was C. albicans (51%). Overall resistance rates to fluconazole, voriconazole, caspofungin, micafungin, and flucytosine were 3.7%, 0%, 2.5%, 1.8%, and 1.8%, respectively. Consequently, there is a need for tests that provide higher success rates, rapid diagnosis of candidemia, and local epidemiological data on antifungal resistance.
dc.identifier.citationAydın, S., Derin, O., Şahin, M., Dinleyici, R., Yılmaz, M., Ceylan, B. ... Mert, A. (2022). Epidemiology of nosocomial candidemia, mortality, and antifungal resistance: 7-year experience in Turkey. Japanese Journal of Infectious Diseases, 75(6), 597-603. https://doi.org/10.7883/yoken.JJID.2022.181
dc.identifier.doi10.7883/yoken.JJID.2022.181
dc.identifier.endpage603
dc.identifier.issn1344-6304
dc.identifier.issue6
dc.identifier.pmid35908875
dc.identifier.scopus2-s2.0-85142216351
dc.identifier.scopusqualityQ3
dc.identifier.startpage597
dc.identifier.urihttps://doi.org/10.7883/yoken.JJID.2022.181
dc.identifier.urihttps://hdl.handle.net/20.500.12511/10072
dc.identifier.volume75
dc.identifier.wos000905077700010en_US
dc.identifier.wosqualityQ4
dc.indekslendigikaynakWeb of Science
dc.indekslendigikaynakScopus
dc.indekslendigikaynakPubMed
dc.institutionauthorAydın, Selda
dc.institutionauthorŞahin, Meyha
dc.institutionauthorDinleyici, Rümeysa
dc.institutionauthorYılmaz, Mesut
dc.institutionauthorCeylan, Bahadır
dc.institutionauthorİstanbullu Tosun, Ayşe
dc.institutionauthorÖztürk, Recep
dc.institutionauthorMert, Ali
dc.language.isoen
dc.publisherNational Institute of Health
dc.relation.ispartofJapanese Journal of Infectious Diseasesen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanı
dc.rightsinfo:eu-repo/semantics/openAccess
dc.subjectAntifungal Resistance
dc.subjectNosocomial Candidemia
dc.subjectEpidemiology
dc.subjectTurkey
dc.titleEpidemiology of nosocomial candidemia, mortality, and antifungal resistance: 7-year experience in Turkey
dc.typeArticle

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