Isolation of anti-inflammatory compounds from Sambucus ebulus leaves through in vitro activity-guided fractionation

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dc.contributor.authorAtay, İrem
dc.contributor.authorİlter, Ayça Zeynep
dc.contributor.authorBagatur, Yeşim
dc.contributor.authorTelci, Dilek
dc.contributor.authorGören, Ahmet
dc.contributor.authorKırmızıbekmez, Hasan
dc.contributor.authorYeşilada, Erdem
dc.date.accessioned10.07.201910:49:13
dc.date.accessioned2019-07-10T20:02:34Z
dc.date.available10.07.201910:49:13
dc.date.available2019-07-10T20:02:34Z
dc.date.issued2015
dc.departmentİstanbul Medipol Üniversitesi, Eczacılık Fakültesi, Eczacılık Meslek Bilimleri Bölümü, Farmakognozi Ana Bilim Dalı
dc.description63rd International Congress and Annual Meeting of the Society-for-Medicinal-Plant-and-Natural-Product-Research (GA) -- August 23-27, 2015 -- Budapest, Hungary
dc.descriptionWOS: 000367558100418
dc.description.abstractThe in vitro anti-inflammatory effects of subextracts (n-hexane, chloroform, ethyl acetate, n-butanol, remaining water) of the methanol extract of the leaves of Sambucus ebulus L. (Adoxaceae) were investigated for their inhibitory activities on the activation of Nuclear factor kappa B (NF-?B) on lipopolysaccharide induced Raw 264.7 cells. The n-hexane, chloroform and ethyl acetate subextracts inhibited NF-?B activation at 50, 100 and 100 µg/mL concentrations, respectively. Two flavonoid mixtures [quercetin-3-O-?-D- glucopyranoside, quercetin-3-O-?-D-galactopyranoside], two flavonoids [isorhamnetin-3-O- ?-D-glucopyranoside (1), isorhamnetin-3-O-rutinoside (2)] were isolated from ethyl acetate subextract. 10-O-acetylpatrinoside (3) and a new iridoid [Sambulin B (4)] was obtained from chloroform and n-hexane subextracts respectively. Structures were elucidated by NMR and MS. The compounds exerted inhibitions between 30 – 80% on NF-?B. Flavonoids were applied to cells at 25, 50, 75 and 100 µg/mL concentrations. Sambulin B was applied at 6,25, 12,5, 25 and Sambulin A applied at 12,5, 25 and 50 µg/mL concentrations.
dc.identifier.citationAtay, İ., İlter, A. Z., Bagatur, Y., Telci, D., Gören, A., Kırmızıbekmez, H. ve Yeşilada, E. (2015). Isolation of anti-inflammatory compounds from Sambucus ebulus leaves through in vitro activity-guided fractionation. 63rd International Congress and Annual Meeting of the Society-for-Medicinal-Plant-and-Natural-Product-Research içinde (1512-1512. ss.). Budapest, Hungary, August 23-27, 2015. https://dx.doi.org/10.1055/s-0035-1565693
dc.identifier.doi10.1055/s-0035-1565693
dc.identifier.endpage1512
dc.identifier.issn0032-0943
dc.identifier.issn1439-0221
dc.identifier.issue16
dc.identifier.startpage1512
dc.identifier.urihttps://hdl.handle.net/20.500.12511/3682
dc.identifier.urihttps://dx.doi.org/10.1055/s-0035-1565693
dc.identifier.volume81
dc.identifier.wosqualityQ1
dc.indekslendigikaynakWeb of Science
dc.language.isoen
dc.publisherGeorg Thieme Verlag
dc.relation.ispartof63rd International Congress and Annual Meeting of the Society-for-Medicinal-Plant-and-Natural-Product-Researchen_US
dc.relation.publicationcategoryKonferans Öğesi - Uluslararası - Kurum Öğretim Elemanı
dc.rightsinfo:eu-repo/semantics/openAccess
dc.subjectIsolation
dc.subjectSambucus
dc.subjectEbulus
dc.titleIsolation of anti-inflammatory compounds from Sambucus ebulus leaves through in vitro activity-guided fractionation
dc.typeConference Object

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