Surface modified multifunctional and stimuli responsive nanoparticles for drug targeting: Current status and uses

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dc.authorid0000-0002-3210-3747
dc.contributor.authorSiafaka, Panoraia I.
dc.contributor.authorOkur Üstündağ, Neslihan
dc.contributor.authorKaravas, Evangelos
dc.contributor.authorBikiaris, Dimitrios N.
dc.date.accessioned10.07.201910:49:13
dc.date.accessioned2019-07-10T19:56:42Z
dc.date.available10.07.201910:49:13
dc.date.available2019-07-10T19:56:42Z
dc.date.issued2016
dc.departmentİstanbul Medipol Üniversitesi, Eczacılık Fakültesi, Temel Eczacılık Bilimleri Bölümü, Farmasötik Mikrobiyoloji Ana Bilim Dalı
dc.descriptionWOS: 000385525500067
dc.descriptionPubMed ID: 27589733
dc.description.abstractNanocarriers, due to their unique features, are of increased interest among researchers working with pharmaceutical formulations. Polymeric nanoparticles and nanocapsules, involving non-toxic biodegradable polymers, liposomes, solid lipid nanoparticles, and inorganic-organic nanomaterials, are among the most used carriers for drugs for a broad spectrum of targeted diseases. In fact, oral, injectable, transdermal-dermal and ocular formulations mainly consist of the aforementioned nanomaterials demonstrating promising characteristics such as long circulation, specific targeting, high drug loading capacity, enhanced intracellular penetration, and so on. Over the last decade, huge advances in the development of novel, safer and less toxic nanocarriers with amended properties have been made. In addition, multifunctional nanocarriers combining chemical substances, vitamins and peptides via coupling chemistry, inorganic particles coated by biocompatible materials seem to play a key role considering that functionalization can enhance characteristics such as biocompatibility, targetability, environmental friendliness, and intracellular penetration while also have limited side effects. This review aims to summarize the state of the art of drug delivery carriers in nanosize, paying attention to their surface functionalization with ligands and other small or polymeric compounds so as to upgrade active and passive targeting, different release patterns as well as cell targeting and stimuli responsibility. Lastly, future aspects and potential uses of nanoparticulated drug systems are outlined.
dc.identifier.citationSiafaka, P. I., Okur Üstündağ, N., Karavas, E. ve Bikiaris, D. N. (2016). Surface modified multifunctional and stimuli responsive nanoparticles for drug targeting: Current status and uses. International Journal Of Molecular Sciences, 17(9). https://dx.doi.org/10.3390/ijms17091440
dc.identifier.doi10.3390/ijms17091440
dc.identifier.issn1422-0067
dc.identifier.issue9
dc.identifier.scopusqualityQ1
dc.identifier.urihttps://dx.doi.org/10.3390/ijms17091440
dc.identifier.urihttps://hdl.handle.net/20.500.12511/2794
dc.identifier.volume17
dc.identifier.wosqualityQ1
dc.indekslendigikaynakWeb of Science
dc.indekslendigikaynakScopus
dc.indekslendigikaynakPubMed
dc.language.isoen
dc.publisherMDPI
dc.relation.ispartofInternational Journal Of Molecular Sciencesen_US
dc.relation.publicationcategoryDiğer
dc.rightsAttribution 4.0 International*
dc.rightsinfo:eu-repo/semantics/openAccess
dc.rights.urihttps://creativecommons.org/licenses/by/4.0/*
dc.subjectMultifunctional Nanocarriers
dc.subjectSurface Modification
dc.subjectDrug Delivery
dc.subjectCell Targeting
dc.subjectStimuli Responsive
dc.subjectToxicity
dc.titleSurface modified multifunctional and stimuli responsive nanoparticles for drug targeting: Current status and uses
dc.typeReview Article

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