ACE2 and LOX enzyme inhibitions of different lavender essential oils and major components linalool and camphor

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dc.authorid0000-0003-1896-2729
dc.authorid0000-0002-3412-0807
dc.contributor.authorBiltekin, Sevde Nur
dc.contributor.authorKaradağ, Ayşe Esra
dc.contributor.authorDemirci, Betül
dc.contributor.authorDemirci, Fatih
dc.date.accessioned2022-12-15T11:11:04Z
dc.date.available2022-12-15T11:11:04Z
dc.date.issued2022
dc.departmentİstanbul Medipol Üniversitesi, Eczacılık Fakültesi, Temel Eczacılık Bilimleri Bölümü, Farmasötik Mikrobiyoloji Ana Bilim Dalı
dc.departmentİstanbul Medipol Üniversitesi, Eczacılık Fakültesi, Eczacılık Meslek Bilimleri Bölümü, Farmakognozi Ana Bilim Dalı
dc.description.abstractIn this present study, Lavandula angustifolia, Lavandula stoechas, and Lavandula x heterophylla essential oils and their main compounds linalool and camphor were evaluated in vitro for lipoxygenase enzyme (LOX) and for angiotensin converting enzyme 2 (ACE2) inhibition potential. The chemical compositions of L. angustifolia, L. stoechas, and L. heterophylla essential oils were confirmed both by gas chromatography-mass spectrometry and gas chromatography-flame ionization detection, where 22.4, 0.9, and 30.6% linalool and 17.8, 54.7, and 15% camphor were identified for each oil among other components, respectively. Enzyme inhibitory activity studies were performed at 20 mu g/mL for the tested essential oils, whereas for linalool and camphor concentrations, 5 mu g/mL was used. The ACE2 inhibitions of L. angustifolia, L. stoechas, and L. heterophylla essential oils were 25.4, 34.1, and 27.1%, while the LOX inhibitions were observed as 79, 49.1, and 86.7%, respectively. In addition, linalool and camphor showed remarkable ACE2 inhibition with 77.1 and 85.1%, whereas the LOX inhibition was observed at 92 and 67.2%, respectively. In conclusion of the initial findings, further detailed in vivo studies are needed to confirm the safe use.
dc.description.sponsorshipAnadolu University Scientific Research Projects Commissionen_US
dc.identifier.citationBiltekin, S. N., Karadağ, A. E., Demirci, B. ve Demirci, F. (2022). ACE2 and LOX enzyme inhibitions of different lavender essential oils and major components linalool and camphor. ACS Omega, 7(41), 36561-36566. https://doi.org/10.1021/acsomega.2c04518
dc.identifier.doi10.1021/acsomega.2c04518
dc.identifier.endpage36566
dc.identifier.issn2470-1343
dc.identifier.issue41
dc.identifier.pmid36278093
dc.identifier.scopus2-s2.0-85139726109
dc.identifier.scopusqualityQ1
dc.identifier.startpage36561
dc.identifier.urihttps://doi.org/10.1021/acsomega.2c04518
dc.identifier.urihttps://hdl.handle.net/20.500.12511/10128
dc.identifier.volume7
dc.identifier.wos000868950800001en_US
dc.identifier.wosqualityQ2
dc.indekslendigikaynakWeb of Science
dc.indekslendigikaynakScopus
dc.indekslendigikaynakPubMed
dc.institutionauthorBiltekin, Sevde Nur
dc.institutionauthorKaradağ, Ayşe Esra
dc.language.isoen
dc.publisherAmerican Chemical Society
dc.relation.ispartofACS Omegaen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanı
dc.rightsinfo:eu-repo/semantics/openAccess
dc.subjectAntimicrobial Agents
dc.subjectInhibition
dc.subjectLipids
dc.subjectOrganic Compounds
dc.subjectPeptides and Proteins
dc.titleACE2 and LOX enzyme inhibitions of different lavender essential oils and major components linalool and camphor
dc.typeArticle

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