The association of oxidative stress and DNA damage with XRCC1 and XRCC3 polymorphisms in radiology technicians

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dc.authorid0000-0002-4899-9146
dc.authorid0000-0002-6393-1465
dc.authorid0000-0002-2018-9619
dc.contributor.authorSöylemez, Esra
dc.contributor.authorÖzçağlı, Eren
dc.contributor.authorKorkmaz, Serol
dc.contributor.authorTok, Olgu Enis
dc.contributor.authorAydın, Mehmet Şerif
dc.contributor.authorOmurtag, Gülden Zehra
dc.date.accessioned2022-03-16T10:56:00Z
dc.date.available2022-03-16T10:56:00Z
dc.date.issued2022
dc.departmentİstanbul Medipol Üniversitesi, Tıp Fakültesi, Temel Tıp Bilimleri Bölümü, Histoloji ve Embriyoloji Ana Bilim Dalı
dc.departmentİstanbul Medipol Üniversitesi, Rektörlük, Rejeneratif ve Restoratif Tıp Araştırmaları Merkezi (REMER)
dc.departmentİstanbul Medipol Üniversitesi, Eczacılık Fakültesi, Eczacılık Meslek Bilimleri Bölümü, Farmasötik Toksikoloji Ana Bilim Dalı
dc.description.abstractIonizing radiation has widespread use in medicine in the diagnosis and treatment of many medical conditions. Radiology technicians are one group that is occupationally exposed to low doses of radiation. There are questions regarding whether low dose exposure to radiation could have long-term health consequences. Assessing the effect of radiation on genetic material is essential for appraising long-term health results. Hereditary variations in DNA repair genes cause differentiation in individual responses to radiation related health effects. This study aimed to determine oxidative stress and DNA damage, and their relationship to XRCC1 (Arg399Gln) and XRCC3 (Thr241Met) polymorphisms in radiology technicians occupationally exposed to low dose radiation. Peripheral blood samples were collected from 45 radiology technicians and age-matched with 40 healthy control individuals working in office environments. Our results showed that radiology technicians had significantly greater oxidative stress and DNA damage than the control group, and women appeared more susceptible to occupational radiation exposure than men. Individuals with wild-type genotypes for XRCC1 (Arg/Arg) and XRCC3 (Thr/Thr) had less DNA damage. Lower DNA damage levels could be explained by the enhanced capacity to repair low dose radiation induced DNA damage. Further studies are needed to evaluate the role of DNA repair genes in individuals that are occupationally exposed to low dose radiation.
dc.identifier.citationSöylemez, E., Özçağlı, E., Korkmaz, S., Tok, O. E., Aydın, M. Ş. ve Omurtag, G. Z. (2022). The association of oxidative stress and DNA damage with XRCC1 and XRCC3 polymorphisms in radiology technicians. Toxicology and Industrial Health, 38(2), 70-79. https://doi.org/10.1177/07482337211062680
dc.identifier.doi10.1177/07482337211062680
dc.identifier.endpage79
dc.identifier.issn0748-2337
dc.identifier.issn1477-0393
dc.identifier.issue2
dc.identifier.pmid35191782
dc.identifier.scopus2-s2.0-85125387496
dc.identifier.scopusqualityQ3
dc.identifier.startpage70
dc.identifier.urihttps://doi.org/10.1177/07482337211062680
dc.identifier.urihttps://hdl.handle.net/20.500.12511/9127
dc.identifier.volume38
dc.identifier.wos000762973200001en_US
dc.identifier.wosqualityQ3
dc.indekslendigikaynakWeb of Science
dc.indekslendigikaynakScopus
dc.indekslendigikaynakPubMed
dc.institutionauthorTok, Olgu Enis
dc.institutionauthorAydın, Mehmet Şerif
dc.institutionauthorOmurtag, Gülden Zehra
dc.language.isoen
dc.publisherSAGE Publications Ltd
dc.relation.ispartofToxicology and Industrial Healthen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanı
dc.rightsinfo:eu-repo/semantics/closedAccess
dc.subjectDNA Damage
dc.subjectOccupational Exposure
dc.subjectOxidative Stress
dc.subjectRadiology Technicians
dc.subjectXRCC1 (Arg399Gln)
dc.subjectXRCC3 (Thr241Met)
dc.titleThe association of oxidative stress and DNA damage with XRCC1 and XRCC3 polymorphisms in radiology technicians
dc.typeArticle

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