The effect of granulocyte colony stimulating factor on genotoxicity in allogeneic peripheral blood stem cell transplantation donors: A prospective case-control study

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dc.authorid0000-0002-6309-7546
dc.contributor.authorÇakmaklı, Hasan Fatih
dc.contributor.authorGökçe, Hafize
dc.contributor.authorSöylemez, Esma
dc.contributor.authorTopçuoğlu, Pervin
dc.contributor.authorKayaaltı, Zeliha
dc.contributor.authorİleri, Dilber Talia
dc.date.accessioned2023-11-07T09:36:29Z
dc.date.available2023-11-07T09:36:29Z
dc.date.issued2023
dc.departmentİstanbul Medipol Üniversitesi, Eczacılık Fakültesi, Eczacılık Meslek Bilimleri Bölümü, Farmasötik Toksikoloji Ana Bilim Dalı
dc.description.abstractBackground. Every year, thousands of donors are exposed to granulocyte-colony stimulating factor (G-CSF) for stem cell mobilization in hematopoietic stem cell transplantations (HSCT). Previous studies about the genotoxicity of G-CSF were inconclusive. In this study, the genotoxic effects of G-CSF in peripheral blood stem cell (PBSC) donors were evaluated prospectively by using three different validated and reliable methods for the first time in the literature to the best of our knowledge. Methods. Donors of PBSC transplantation (n=36), who received G-CSF were evaluated for genotoxicity by micronucleus test (MNT), nuclear division index (NDI), and comet assay (CA). Genotoxic effects are expected to cause an increase in MNT and CA values and decrease in NDI. Blood samples were collected at three time-points (TP): before starting G-CSF (TP1), after G-CSF for five days (TP2), and one month after the last dose (TP3). Sixteen controls were included for baseline comparison of genotoxicity tests. CD34 cell counts and hemograms were also analyzed. Results. MNT and CA parameters; comet and tail length, tail DNA%, and tail moment, showed no change in time whereas another CA parameter, Olive’s tail moment (OTM) was increased significantly at TP3 compared to both baseline and TP2 (p=0.002 and p=0.017, respectively). Nuclear division index decreased significantly at TP2 (p[removed]
dc.description.sponsorshipAnkara University Scientific Study Funden_US
dc.identifier.citationÇakmaklı, H. F., Gökçe, H., Söylemez, E., Topçuoğlu, P., Kayaaltı, Z. ve İleri, D. T. (2023). The effect of granulocyte colony stimulating factor on genotoxicity in allogeneic peripheral blood stem cell transplantation donors: A prospective case-control study. Turkish Journal of Pediatrics, 65(5), 809-821. https://dx.doi.org/10.24953/turkjped.2023.469
dc.identifier.doi10.24953/turkjped.2023.469
dc.identifier.endpage821
dc.identifier.issn0041-4301
dc.identifier.issn2791-6421
dc.identifier.issue5
dc.identifier.pmid37853972
dc.identifier.scopus2-s2.0-85174750048
dc.identifier.scopusqualityQ3
dc.identifier.startpage809
dc.identifier.urihttps://dx.doi.org/10.24953/turkjped.2023.469
dc.identifier.urihttps://hdl.handle.net/20.500.12511/11717
dc.identifier.volume65
dc.identifier.wos001089229600010en_US
dc.identifier.wosqualityQ4
dc.indekslendigikaynakWeb of Science
dc.indekslendigikaynakScopus
dc.indekslendigikaynakPubMed
dc.institutionauthorSöylemez, Esma
dc.language.isoen
dc.publisherTurkish National Pediatric Society
dc.relation.ispartofTurkish Journal of Pediatricsen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanı
dc.rightsinfo:eu-repo/semantics/openAccess
dc.subjectComet Assay
dc.subjectGenotoxicity Tests
dc.subjectGranulocyte Colony-Stimulating Factor
dc.subjectHematopoietic Stem Cell Donor
dc.subjectHematopoietic Stem Cell Mobilization
dc.subjectMicronucleus Tests
dc.subjectPeripheral Blood Stem Cell Transplantation
dc.subjectTissue Donor
dc.titleThe effect of granulocyte colony stimulating factor on genotoxicity in allogeneic peripheral blood stem cell transplantation donors: A prospective case-control study
dc.typeArticle

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