Nanodrugs for the treatment of ischemic stroke: A systematic review

Basit Öğe Kaydı
dc.authorid0000-0001-6494-8923
dc.contributor.authorRuscu, Mihai
dc.contributor.authorCercel, Andreea
dc.contributor.authorKılıç, Ertuğrul
dc.contributor.authorÇatalın, Boğdan
dc.contributor.authorGresita, Andrei
dc.contributor.authorHermann, Dirk M.
dc.contributor.authorAlbu, Carmen Valeria
dc.contributor.authorPopa-Wagner, Aurel
dc.date.accessioned2023-08-07T08:07:49Z
dc.date.available2023-08-07T08:07:49Z
dc.date.issued2023
dc.departmentİstanbul Medipol Üniversitesi, Tıp Fakültesi, Temel Tıp Bilimleri Bölümü, Fizyoloji Ana Bilim Dalı
dc.description.abstractIschemic stroke, a significant neurovascular disorder, currently lacks effective restorative medication. However, recently developed nanomedicines bring renewed promise for alleviating ischemia’s effects and facilitating the healing of neurological and physical functions. The aim of this systematic review was to evaluate the efficacy of nanotherapies in animal models of stroke and their potential impact on future stroke therapies. We also assessed the scientific quality of current research focused on nanoparticle-based treatments for ischemic stroke in animal models. We summarized the effectiveness of nanotherapies in these models, considering multiple factors such as their anti-inflammatory, antioxidant, and angiogenetic properties, as well as their safety and biodistribution. We conclude that the application of nanomedicines may reduce infarct size and improve neurological function post-stroke without causing significant organ toxicity.
dc.description.sponsorshipUniversity of Medicine and Pharmacy of Craiova ; European Social Funden_US
dc.identifier.citationRuscu, M., Cercel, A., Kılıç, E., Çatalın, B., Gresita, A., Hermann, D. M. ... Popa-Wagner, A. (2023). Nanodrugs for the treatment of ischemic stroke: A systematic review. International Journal of Molecular Sciences, 24(13). https://dx.doi.org/10.3390/ijms241310802
dc.identifier.doi10.3390/ijms241310802
dc.identifier.issn1661-6596
dc.identifier.issn1422-0067
dc.identifier.issue13
dc.identifier.pmid37445979
dc.identifier.scopus2-s2.0-85165054503
dc.identifier.scopusqualityQ1
dc.identifier.urihttps://dx.doi.org/10.3390/ijms241310802
dc.identifier.urihttps://hdl.handle.net/20.500.12511/11277
dc.identifier.volume24
dc.identifier.wos001033233200001en_US
dc.identifier.wosqualityQ1
dc.indekslendigikaynakWeb of Science
dc.indekslendigikaynakScopus
dc.indekslendigikaynakPubMed
dc.institutionauthorKılıç, Ertuğrul
dc.language.isoen
dc.publisherMDPI
dc.relation.ispartofInternational Journal of Molecular Sciencesen_US
dc.relation.publicationcategoryDiğer
dc.rightsAttribution 4.0 International*
dc.rightsinfo:eu-repo/semantics/openAccess
dc.rights.urihttps://creativecommons.org/licenses/by/4.0/*
dc.subjectAnimal Models
dc.subjectBiodistribution
dc.subjectNanodrugs
dc.subjectNeuroinflammation
dc.subjectNeurorestoration
dc.subjectStroke
dc.subjectToxicity
dc.titleNanodrugs for the treatment of ischemic stroke: A systematic review
dc.typeReview Article

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