Formulation development of Silybum marianum seed extracts and silymarin nanoparticles, and evaluation of hepatoprotective effect

Basit Öğe Kaydı
dc.authorid0000-0002-5532-2395
dc.contributor.authorMacit, Meltem
dc.contributor.authorDuman, Gülengül
dc.contributor.authorCumbul, Alev
dc.contributor.authorSümer, Engin
dc.contributor.authorMacit, Çağlar
dc.date.accessioned2023-04-26T06:09:47Z
dc.date.available2023-04-26T06:09:47Z
dc.date.issued2023
dc.departmentİstanbul Medipol Üniversitesi, Eczacılık Fakültesi, Eczacılık Meslek Bilimleri Bölümü, Farmakoloji Ana Bilim Dalı
dc.description.abstractIn this study, we formulated silymarin-nanoparticles and assayed their ability to reduce acetaminophen-induced toxicity in vitro and in vivo. After silymarin molecules were encapsulated the loading efficiency and the physicochemical properties of fabricated nanoparticles were investigated by HPLC and DLS analysis. The in vivo hepatoprotective studies were conducted on rats in an optimized setting. The nanoformulation was presented a significant (p ? 0.05) hepatoprotective effect by reducing the serum marker enzymes such as AST, and ALT. The histopathological study further confirmed the hepatoprotective activity of the nanoformulations when compared with the acetaminophen-induced, two different silymarin formulations as treatment group and control group. These results indicate that the nano approaches could be used to improve the therapeutic efficacy of the nano-silymarin. The formulation of silymarin-nanoparticles showed a spherical shape with an average diameter between 138.9 nm and 1155 nm, the zeta potential of – 0.0340 mV. The average loading efficiency was found around 32 ± 0.5%.
dc.description.sponsorshipYeditepe University department of Technology Tranfer Officeen_US
dc.identifier.citationMacit, M., Duman, G., Cumbul, A., Sümer, E. ve Macit, Ç. (2023). Formulation development of Silybum marianum seed extracts and silymarin nanoparticles, and evaluation of hepatoprotective effect. Journal of Drug Delivery Science and Technology, 83. https://dx.doi.org/10.1016/j.jddst.2023.104378
dc.identifier.doi10.1016/j.jddst.2023.104378
dc.identifier.issn1773-2247
dc.identifier.issn2588-8943
dc.identifier.scopus2-s2.0-85151902276
dc.identifier.scopusqualityQ1
dc.identifier.urihttps://dx.doi.org/10.1016/j.jddst.2023.104378
dc.identifier.urihttps://hdl.handle.net/20.500.12511/10890
dc.identifier.volume83
dc.identifier.wos000974910100001en_US
dc.identifier.wosqualityQ2
dc.indekslendigikaynakWeb of Science
dc.indekslendigikaynakScopus
dc.institutionauthorMacit, Çağlar
dc.language.isoen
dc.publisherEditions de Sante
dc.relation.ispartofJournal of Drug Delivery Science and Technologyen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanı
dc.rightsinfo:eu-repo/semantics/embargoedAccess
dc.subjectALT and AST
dc.subjectExtraction
dc.subjectLiver
dc.subjectMilk Thistle
dc.subjectSilymarin
dc.titleFormulation development of Silybum marianum seed extracts and silymarin nanoparticles, and evaluation of hepatoprotective effect
dc.typeArticle

Dosyalar

Orijinal paket
Listeleniyor 1 - 1 / 1
Küçük Resim Yok
İsim:
Macit-Caglar-2023.pdf
Boyut:
3.88 MB
Biçim:
Adobe Portable Document Format
Açıklama:
Tam Metin / Full Text
İndir
Lisans paketi
Listeleniyor 1 - 1 / 1
Küçük Resim Yok
İsim:
license.txt
Boyut:
1.44 KB
Biçim:
Item-specific license agreed upon to submission
Açıklama:
İndir

Koleksiyon

Eczacılık Fakültesi Makale Koleksiyonu
Scopus İndeksli Yayınlar Koleksiyonu
WoS İndeksli Yayınlar Koleksiyonu