Spinal cord stereology

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dc.authorid0000-0002-6984-3079
dc.contributor.authorKaplan, Süleyman
dc.contributor.authorAltun, Gamze
dc.contributor.authorElamin, Abdalla Ahmed Eldaw
dc.contributor.authorKaplan, Arife Ahsen
dc.contributor.authorMarangoz, Abdullah Hilmi
dc.contributor.authorDeniz, Ömür Gülsüm
dc.date.accessioned2024-11-05T12:22:40Z
dc.date.available2024-11-05T12:22:40Z
dc.date.issued2024
dc.departmentİstanbul Medipol Üniversitesi, Tıp Fakültesi, Temel Tıp Bilimleri Bölümü, Histoloji ve Embriyoloji Ana Bilim Dalı
dc.description.abstractDamage to the spinal cord can lead to significant economic and psychological consequences. Morphoquantitative changes play an important role in determining damage, as well as treatment. The development of light microscopic research in parallel with technology means that morphometric evaluation of neurons, dendritic processes and nerve fibres as well as the whole spinal cord structure can be performed with design-based stereology. Stereological approaches are used for the quantitative analysis of neurodegeneration and regeneration in the central nervous system after trauma and diseases. Optical and physical disector that are stereological techniques have been used in the quantitative evaluation of motor neurons in the spinal cord. The most critical point during cell counting is to correctly classify neuron types using appropriate staining and identification methods. Stereological approaches are also effectively used in radiological evaluations such as magnetic resonance imaging. Evaluations can be performed using the Cavalieri principle in sections obtained from radiological images as well as from light microscopic section images. Unbiased stereological methods are also used for immunohistochemical evaluations. Quantitative evaluations in the spinal cord are especially important in determining the degenerative effect that occurs after injury. In addition, new nanomorphometric information can be acquired with the rotator, optical disector and physical disector methods by providing mapping at the organelle level using the immunogold labelling method. This chapter discusses studies involving the scope of spinal cord evaluation together with the stereological methods applied in radiological, histological and immunohistochemical spinal cord sections.
dc.identifier.citationKaplan, S., Altun, G., Elamin, A. A. E., Kaplan, A. A., Marangoz, A. H. ve Deniz, Ö. G. (2024). Spinal cord stereology. A Manual of the Stereological Techniques içinde (185-202. ss.). Nova Science Publishers, Inc.
dc.identifier.endpage202
dc.identifier.isbn9798891138940
dc.identifier.isbn9798891137707
dc.identifier.scopus2-s2.0-85201349943
dc.identifier.scopusqualityN/A
dc.identifier.startpage185
dc.identifier.urihttps://hdl.handle.net/20.500.12511/12863
dc.indekslendigikaynakScopus
dc.institutionauthorKaplan, Arife Ahsen
dc.language.isoen
dc.publisherNova Science Publishers, Inc.
dc.relation.ispartofA Manual of the Stereological Techniquesen_US
dc.relation.publicationcategoryKitap Bölümü - Uluslararası
dc.rightsinfo:eu-repo/semantics/closedAccess
dc.subjectDisector
dc.subjectMotor Neuron
dc.subjectQuantitative Immunohistochemistry
dc.subjectSpinal Cord
dc.subjectVolume Estimation
dc.titleSpinal cord stereology
dc.typeBook Chapter

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