The effect of obesity on human reproductive health and foetal life

Basit Öğe Kaydı
dc.authorid0000-0001-9377-888X
dc.contributor.authorİncedal Irgat, Serap
dc.contributor.authorBakırhan, Hande
dc.date.accessioned2023-03-07T11:11:22Z
dc.date.available2023-03-07T11:11:22Z
dc.date.issued2022
dc.departmentİstanbul Medipol Üniversitesi, Sağlık Bilimleri Fakültesi, Beslenme ve Diyetetik Bölümü
dc.description.abstractObesity in both women and men is regarded as one of the many factors that may contribute to impaired reproductive health. Obesity can be accompanied by several neuroendocrine and ovarian dysfunctions, including chronic oligo/anovulation, menstrual irregularities, subfertility, and the increased risk of pregnancy in women. Insulin resistance, elevated triglyceride and fatty acid levels, and the secretion of adipocytokines caused by the excessive accumulation of adipose tissue associated with obesity adversely affect reproductive functions. Alterations in sperm quality and motility and hormone levels related to a rise in body mass index (BMI) may predispose men to infertility. The mechanisms of action of obesity on male infertility include endocrinopathy, erectile dysfunction, epididymitis, increased leptin and adipocytes, increased aromatase, inflammatory cytokines secreted by fat tissue, and sperm DNA fragmentation. This study reports that an increased BMI may lead to low semen quality, poor sperm motility, and reduced fertilization rates in men as well as anovulation, pregnancy loss, diminished pregnancy, and low live birth rates in women. Having optimal weight with balanced nutrition enables one to maintain a continuity of reproductive health throughout the entire life cycle, which is extremely important in terms of having a healthy embryo, including pre-foetal life, in the continuity of pregnancy and having a live birth.
dc.identifier.citationİncedal Irgat, S. ve Bakırhan, H. (2022). The effect of obesity on human reproductive health and foetal life. Human Fertility, 25(5), 860-871. https://dx.doi.org/10.1080/14647273.2021.1928774
dc.identifier.doi10.1080/14647273.2021.1928774
dc.identifier.endpage871
dc.identifier.issn1464-7273
dc.identifier.issn1742-8149
dc.identifier.issue5
dc.identifier.pmid34020572
dc.identifier.scopus2-s2.0-85106240812
dc.identifier.scopusqualityQ3
dc.identifier.startpage860
dc.identifier.urihttps://dx.doi.org/10.1080/14647273.2021.1928774
dc.identifier.urihttps://hdl.handle.net/20.500.12511/10578
dc.identifier.volume25
dc.identifier.wos000652994000001en_US
dc.identifier.wosqualityQ4
dc.indekslendigikaynakWeb of Science
dc.indekslendigikaynakScopus
dc.indekslendigikaynakPubMed
dc.institutionauthorBakırhan, Hande
dc.language.isoen
dc.publisherTaylor and Francis Ltd.
dc.relation.ispartofHuman Fertilityen_US
dc.relation.publicationcategoryDiğer
dc.rightsinfo:eu-repo/semantics/embargoedAccess
dc.subjectObesity
dc.subjectReproductive Health
dc.subjectInfertility
dc.subjectFoetal Life
dc.titleThe effect of obesity on human reproductive health and foetal life
dc.typeReview Article

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