A novel approach for skin infections: Controlled release topical mats of poly (lactic acid)/poly(ethylene succinate) blends containing Voriconazole

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dc.authorid0000-0002-3210-3747
dc.authorid0000-0003-2143-5268
dc.contributor.authorÜstündağ Okur, Neslihan
dc.contributor.authorFilippousi, Maria
dc.contributor.authorOkur, Mehmet Evren
dc.contributor.authorAyla, Şule
dc.contributor.authorÇağlar, Emre Şefik
dc.contributor.authorYoltaş, Ayşegül
dc.contributor.authorSiafaka, Panoraia I
dc.date.accessioned10.07.201910:49:13
dc.date.accessioned2019-07-10T19:50:25Z
dc.date.available10.07.201910:49:13
dc.date.available2019-07-10T19:50:25Z
dc.date.issued2018
dc.departmentİstanbul Medipol Üniversitesi, Eczacılık Fakültesi, Eczacılık Teknolojisi Bölümü, Farmasötik Teknoloji Ana Bilim Dalı
dc.departmentİstanbul Medipol Üniversitesi, Tıp Fakültesi, Temel Tıp Bilimleri Bölümü, Histoloji ve Embriyoloji Ana Bilim Dalı
dc.descriptionWOS: 000438500700010
dc.description.abstractThe oral and injectable formulations of Voriconazole (VRZ), a known antifungal agent with low solubility, seem to cause severe side effects. Consequently, topical application of VRZ could be advantageous for skin fungal infections. In this study, VRZ embedded in a polymeric matrix composed of biocompatible poly(lactic acid) (PLA) and poly(ethylene succinate) (PESu). The mats were prepared via solvent evaporation and fully characterized by Fourier-Transformed Infrared Spectroscopy (FTIR), Differential Scanning Calorimetry (DSC), Scanning Electron Microscopy (SEM), in vitro hydrolysis and release studies. The prepared blends defined as immiscible by DSC and SEM while FTIR spectroscopy did not disclose noticeable interactions between the polymers. It was found that hydrolysis was improved by increasing PESu content into the blend. VRZ loaded blends spectra exhibit slight differentiation compared to neat blends while the absence of VRZ melting peak, as DSC illustrated, indicated drug amorphization. Lastly, in vitro release studies depicted a controlled release pattern dependent on mats' hydrolysis degree. An improved antifungal activity of mats was detected by disc diffusion method against various microorganisms. Ex vivo studies of VRZ did not determine high permeation while histopathology results using mice were profitable. The irritation experiments displayed that the mats did not induce any skin irritation.
dc.identifier.citationÜstündağ Okur, N., Filippousi, M., Okur, M. E., Ayla, Ş., Çağlar, E., Yoltaş, A. ... Siafaka, P. (2018). A novel approach for skin infections: Controlled release topical mats of poly (lactic acid)/poly(ethylene succinate) blends containing Voriconazole. Journal of Drug Delivery Science and Technology, 46, 74-86. https://dx.doi.org/10.1016/j.jddst.2018.05.005
dc.identifier.doi10.1016/j.jddst.2018.05.005
dc.identifier.endpage86
dc.identifier.issn1773-2247
dc.identifier.scopusqualityQ2
dc.identifier.startpage74
dc.identifier.urihttps://dx.doi.org/10.1016/j.jddst.2018.05.005
dc.identifier.urihttps://hdl.handle.net/20.500.12511/1977
dc.identifier.volume46
dc.identifier.wosqualityQ2
dc.indekslendigikaynakWeb of Science
dc.indekslendigikaynakScopus
dc.language.isoen
dc.publisherElsevier Science Bv
dc.relation.ispartofJournal of Drug Delivery Science and Technologyen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanı
dc.rightsinfo:eu-repo/semantics/openAccess
dc.subjectFungal Infections
dc.subjectVoriconazole
dc.subjectTopical Mat
dc.subjectDressing
dc.subjectDrug Delivery
dc.subjectAntifungal
dc.titleA novel approach for skin infections: Controlled release topical mats of poly (lactic acid)/poly(ethylene succinate) blends containing Voriconazole
dc.typeArticle

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