Synthesis, antimicrobial and antioxidant activities of pyridyl substituted thiazolyl triazole derivatives
| dc.authorid | 0000-0002-0841-1299 | |
| dc.contributor.author | Tay, Naime Funda | |
| dc.contributor.author | Duran, Murat | |
| dc.contributor.author | Kayagil, İsmail | |
| dc.contributor.author | Yurttaş, Leyla | |
| dc.contributor.author | Göger, Gamze | |
| dc.contributor.author | Göğer, Fatih | |
| dc.contributor.author | Demirci, Fatih | |
| dc.contributor.author | Demirayak, Şeref | |
| dc.date.accessioned | 2022-08-05T11:13:04Z | |
| dc.date.available | 2022-08-05T11:13:04Z | |
| dc.date.issued | 2022 | |
| dc.department | İstanbul Medipol Üniversitesi, Eczacılık Fakültesi, Eczacılık Meslek Bilimleri Bölümü, Farmasötik Kimya Ana Bilim Dalı | |
| dc.description.abstract | In this present study, 63 different 5-[4-methyl-2-(pyridin-3/4-yl)thiazole-5-yl]-4-substituted-3-substituted benzylthio-4H-1,2,4-triazole derivatives were synthesized, and evaluated for their in vitro antimicrobial activity against various human pathogenic microorganisms and antioxidant activity. The derivatives were synthesized in a multi-step synthesis procedure including triazole and thiazole ring closure reactions, respectively. The synthesized derivatives (A1-24; B1-39) were screened for their antibacterial, antifungal, and antioxidant activities compared to standard agents. The derivatives possessing 3-pyridyl moiety particularly exhibited relatively high antibacterial activity (MIC= < 3.09-500 µg/mL) against Gram-positive bacteria, and compounds possessing 4-pyridyl moiety showed remarkable antioxidant activity. | |
| dc.description.sponsorship | Eskisehir Osmangazi University | en_US |
| dc.identifier.citation | Tay, Naime F., Duran, M., Kayagil, İ., Yurttaş, L., Göger, G., Göğer, F. ... Demirayak, Ş. (2022). Synthesis, antimicrobial and antioxidant activities of pyridyl substituted thiazolyl triazole derivatives. Brazilian Journal of Pharmaceutical Sciences, 58. https://doi.org/10.1590/s2175-97902022e191026 | |
| dc.identifier.doi | 10.1590/s2175-97902022e191026 | |
| dc.identifier.issn | 1984-8250 | |
| dc.identifier.issn | 2175-9790 | |
| dc.identifier.scopus | 2-s2.0-85129728009 | |
| dc.identifier.scopusquality | Q2 | |
| dc.identifier.uri | https://doi.org/10.1590/s2175-97902022e191026 | |
| dc.identifier.uri | https://hdl.handle.net/20.500.12511/9632 | |
| dc.identifier.volume | 58 | |
| dc.identifier.wos | 000828470900001 | en_US |
| dc.identifier.wosquality | Q4 | |
| dc.indekslendigikaynak | Web of Science | |
| dc.indekslendigikaynak | Scopus | |
| dc.institutionauthor | Demirayak, Şeref | |
| dc.language.iso | en | |
| dc.publisher | Universidade de São Paulo | |
| dc.relation.ispartof | Brazilian Journal of Pharmaceutical Sciences | en_US |
| dc.relation.publicationcategory | Makale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanı | |
| dc.rights | Attribution 4.0 International | * |
| dc.rights | info:eu-repo/semantics/openAccess | |
| dc.rights.uri | https://creativecommons.org/licenses/by/4.0/ | * |
| dc.subject | Antimicrobial Activity | |
| dc.subject | Antioxidant Activity | |
| dc.subject | DPPH Radical Scavenging | |
| dc.subject | Pyridine | |
| dc.subject | Thiazole | |
| dc.subject | Triazole | |
| dc.title | Synthesis, antimicrobial and antioxidant activities of pyridyl substituted thiazolyl triazole derivatives | |
| dc.type | Article |
