Antimicrobial evaluation of trisubstituted 2-piperazinyl thiazoles

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dc.authorid0000-0003-1318-6476
dc.authorid0000-0002-5976-676X
dc.authorid0000-0001-6047-2796
dc.authorid0000-0002-0841-1299
dc.contributor.authorGiray, Betül
dc.contributor.authorYurttaş, Leyla
dc.contributor.authorŞahin, Zafer
dc.contributor.authorBerk, Barkın
dc.contributor.authorDemirayak, Şeref
dc.date.accessioned10.07.201910:49:13
dc.date.accessioned2019-07-10T19:36:10Z
dc.date.available10.07.201910:49:14
dc.date.available2019-07-10T19:36:10Z
dc.date.issued2019
dc.departmentİstanbul Medipol Üniversitesi, Eczacılık Fakültesi, Eczacılık Meslek Bilimleri Bölümü, Farmasötik Kimya Ana Bilim Dalı
dc.description.abstractThiazole and basic nitrogen containing rings are important chemical moieties of antimicrobial drugs. In recent, third generation cephalosporins include thiazole ring system. In this study, we synthesized 33 piperazine thiazole derivatives which were thought to show antimicrobial activity. Synthesize were realized with good yield using the method which reports the anticholinesterase properties of these compounds. Similar compounds with the same scaffold (2, 4, 5 trisubstituted thiazoles) are investigated for antimicrobial activity. Compounds 23-27 exhibited MIC: 256 µM against S. aureus ATCC 25923. Besides, 27-33 group showed MIC: 256 µM against K. pneumoniae UC57 and B. cereus. It is remarkable that the compound 27 showed antimicrobial activity against 4 different microorganisms and 26 showed antimicrobial activity against L. monocytogenes by MIC: 32 µM which is same as the standart chloramphenicol.
dc.identifier.citationGiray, B., Yurttaş, L., Şahin, Z., Berk, B. ve Demirayak, Ş. (2019). Antimicrobial evaluation of trisubstituted 2-piperazinyl thiazoles. Acta Pharmaceutica Sciencia, 57(1), 103-108. https://dx.doi.org/10.23893/1307-2080.APS.05707
dc.identifier.doi10.23893/1307-2080.APS.05707
dc.identifier.endpage108
dc.identifier.issn1307-2080
dc.identifier.issue1
dc.identifier.scopusqualityQ3
dc.identifier.startpage103
dc.identifier.urihttps://hdl.handle.net/20.500.12511/1084
dc.identifier.urihttps://dx.doi.org/10.23893/1307-2080.APS.05707
dc.identifier.volume57
dc.indekslendigikaynakScopus
dc.language.isoen
dc.publisherİstanbul Medipol University
dc.relation.ispartofActa Pharmaceutica Scienciaen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanı
dc.rightsinfo:eu-repo/semantics/openAccess
dc.subjectAntimicrobial
dc.subjectN-Benzoylthioamide
dc.subjectPiperazine
dc.subjectThiazole
dc.subjectTrisubstituted Thiazole
dc.titleAntimicrobial evaluation of trisubstituted 2-piperazinyl thiazoles
dc.typeArticle

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