In vitro anti-inflammatory activities of Tanacetum parthenium L. extract and its major metabolite parthenolide

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dc.authorid0009-0008-3754-0293
dc.authorid0000-0002-3412-0807
dc.authorid0000-0003-1896-2729
dc.authorid0000-0001-9696-3271
dc.contributor.authorBaydar, Rengin
dc.contributor.authorKaradağ, Ayşe Esra
dc.contributor.authorBiltekin, Sevde Nur
dc.contributor.authorGüzelmeriç, Etil
dc.contributor.authorDemirci, Fatih
dc.date.accessioned2024-02-07T12:03:50Z
dc.date.available2024-02-07T12:03:50Z
dc.date.issued2024
dc.departmentİstanbul Medipol Üniversitesi, Eczacılık Fakültesi, Eczacılık Meslek Bilimleri Bölümü, Farmakognozi Ana Bilim Dalı
dc.departmentİstanbul Medipol Üniversitesi, Eczacılık Fakültesi, Temel Eczacılık Bilimleri Bölümü, Farmasötik Mikrobiyoloji Ana Bilim Dalı
dc.description.abstractTanacetum parthenium L. (Feverfew) is daisy-like Asteraceae plant carrying sesquiterpene lactones; used for the treatment of migraine and anti-inflamma-tory effect. This study aims to evaluate T. parthenium extract and major metabolite parthenolide for in vitro COX-1/COX-2, LOX inhibitory activity. The extract analyzed by HPTLC. To evaluate COX-1/COX-2 inhibition assays, stud-ied with commercial kits (20µg/mL concentration for extract, 5 µg/mL for par-thenolide). The major component of extract characterized as parthenolide. IC50 values for COX-1/COX-2 inhibition of extract were 10.45 and 9.81µg/mL, for parthenolide; 4.86 and 1.90µg/mL. SI values of T. parthenium extract and par-thenolide were 0.93 and 0.39. Extract showed selective COX-2 inhibitory activ-ity. The inhibition value of extract on LOX was 80% and inhibition value of par-thenolide was 41.13%. The results suggested that T. parthenium extract showed selective potential for COX-2 enzyme inhibition. To the best of our knowledge, the extract was tested with COX-1, COX-2, and LOX enzymes for the first time.
dc.description.sponsorshipIstanbul Medipol University Scientific Research Project Commisssionen_US
dc.identifier.citationBaydar, R., Karadağ, A. E., Biltekin, S. N., Güzelmeriç, E. ve Demirci, F. (2024). In vitro anti-inflammatory activities of Tanacetum parthenium L. extract and its major metabolite parthenolide. Acta Pharmaceutica Sciencia, 62(1), 183-192. https://dx.doi.org/10.23893/1307-2080.APS6212
dc.identifier.doi10.23893/1307-2080.APS6212
dc.identifier.endpage192
dc.identifier.issn1307-2080
dc.identifier.issue1
dc.identifier.scopus2-s2.0-85183028761
dc.identifier.scopusqualityQ3
dc.identifier.startpage183
dc.identifier.urihttps://dx.doi.org/10.23893/1307-2080.APS6212
dc.identifier.urihttps://hdl.handle.net/20.500.12511/12249
dc.identifier.volume62
dc.indekslendigikaynakScopus
dc.institutionauthorBaydar, Rengin
dc.institutionauthorKaradağ, Ayşe Esra
dc.institutionauthorBiltekin, Sevde Nur
dc.institutionauthorGüzelmeriç, Etil
dc.language.isoen
dc.publisherIstanbul Medipol University
dc.relation.ispartofActa Pharmaceutica Scienciaen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanı
dc.rightsinfo:eu-repo/semantics/openAccess
dc.subjectAnti-Inflammatory
dc.subjectCOX
dc.subjectFeverfew
dc.subjectLOX
dc.subjectTanacetum Parthenium
dc.titleIn vitro anti-inflammatory activities of Tanacetum parthenium L. extract and its major metabolite parthenolide
dc.typeArticle

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