Sprayable microemulsion of diphenhydramine hydrochloride for dermal delivery

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dc.authorid0000-0001-9290-2404
dc.authorid0009-0002-7466-9842
dc.contributor.authorArpa, Muhammet Davut
dc.contributor.authorArslan, Tuğba
dc.contributor.authorEraslan, Huriye
dc.contributor.authorÜstündağ Okur, Neslihan
dc.date.accessioned2024-05-08T17:24:07Z
dc.date.available2024-05-08T17:24:07Z
dc.date.issued2024
dc.departmentİstanbul Medipol Üniversitesi, Eczacılık Fakültesi, Eczacılık Teknolojisi Bölümü, Farmasötik Teknoloji Ana Bilim Dalı
dc.description.abstractIn this work, a sprayable microemulsion of diphenhydramine hydrochloride (DPH HCl) was developed for use in conditions that cause itching, such as insect bites, mild sunburns, and skin irritations. Microemulsions were prepared using oleic acid and isopropyl myristate as the oil phase (1:2), Tween 20 and Transcutol HP as surfactants, isopropyl alcohol as co-surfactant, and water. The microemulsions (M1, M2, and M3) that presented greater area were selected as lead microemulsions and loaded with 2% DPH HCl (w/w). The physical stabilities of drug-loaded formulations with a droplet size of 15.998-19.030 nm, polydispersity index of 0.404-0.516, and turbidity of 2.41-2.50 Ntu were evaluated as appropriate. The microemulsions showed a great spread area in sprayability studies. Moreover, DPH HCl release from microemulsions reached 80-100% within one hour. The sprayable microemulsions were highly suitable for topical application of DPH HCl and can be evaluated for clinical applications with further studies.
dc.identifier.citationArpa, M. D., Arslan, T., Eraslan, H. ve Üstündağ Okur, N. (2024). Sprayable microemulsion of diphenhydramine hydrochloride for dermal delivery. Acta Pharmaceutica Sciencia, 62(2), 462-479. http://dx.doi.org/10.23893/1307-2080.APS6229
dc.identifier.doi10.23893/1307-2080.APS6229
dc.identifier.endpage479
dc.identifier.issn1307-2080
dc.identifier.issue2
dc.identifier.scopus2-s2.0-85189200043
dc.identifier.scopusqualityQ3
dc.identifier.startpage462
dc.identifier.urihttp://dx.doi.org/10.23893/1307-2080.APS6229
dc.identifier.urihttps://hdl.handle.net/20.500.12511/12441
dc.identifier.volume62
dc.indekslendigikaynakScopus
dc.institutionauthorArpa, Muhammet Davut
dc.institutionauthorArslan, Tuğba
dc.institutionauthorEraslan, Huriye
dc.language.isoen
dc.relation.ispartofActa Pharmaceutica Scienciaen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanı
dc.rightsinfo:eu-repo/semantics/openAccess
dc.subjectDermal Delivery
dc.subjectDiphenhydramine Hydrochloride
dc.subjectMicroemulsion
dc.subjectTopical Application
dc.subjectTopical Spray
dc.titleSprayable microemulsion of diphenhydramine hydrochloride for dermal delivery
dc.typeArticle

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