In vitro antitumor activity evaluation of some 1,2,4-triazine derivatives bearing piperazine amide moiety against breast cancer cells

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dc.contributor.authorYurttaş, Leyla
dc.contributor.authorDemirayak, Şeref
dc.contributor.authorIlgın, Sinem
dc.contributor.authorAtlı, Özlem
dc.date.accessioned10.07.201910:49:13
dc.date.accessioned2019-07-10T19:35:42Z
dc.date.available10.07.201910:49:14
dc.date.available2019-07-10T19:35:42Z
dc.date.issued2014
dc.departmentİstanbul Medipol Üniversitesi, Eczacılık Fakültesi, Eczacılık Meslek Bilimleri Bölümü, Farmasötik Kimya Ana Bilim Dalı
dc.description.abstractA series of 1,2,4-triazine derivatives bearing piperazine amide moiety has been synthesized and investigated for their potential anticancer activities. 1-[4-(5,6-Bis (4-subtituted phenyl) -1,2,4-triazin-3-yl)piperazin-1-yl]-2-[4-(3-substituted phenyl) piperazin-1-yl]ethanone derivative (1-32) compounds were synthesized by a four step synthetic procedure. The activity studies were evaluated using XTT method, BrdU method and flow cytometric analysis on MCF-7 breast cancer cells and NIH/3T3 (mouse embryonic fibroblast cells) healthy cells. Compounds 5 with 3-chlorophenyl and compound 7 with 4-chlorophenyl substitutions were found to be promising antiproliferative agents comparing with an effective anticancer drug, cisplatin.
dc.identifier.citationYurttaş, L., Demirayak, Ş., Ilgın, S. ve Atlı, Ö. (2014). In vitro antitumor activity evaluation of some 1,2,4-triazine derivatives bearing piperazine amide moiety against breast cancer cells. Bioorganic and Medicinal Chemistry, 22(22), 6313-6323. https://dx.doi.org/10.1016/j.bmc.2014.10.002
dc.identifier.doi10.1016/j.bmc.2014.10.002
dc.identifier.endpage6323
dc.identifier.issn0968-0896
dc.identifier.issue22
dc.identifier.scopusqualityQ1
dc.identifier.startpage6313
dc.identifier.urihttps://dx.doi.org/10.1016/j.bmc.2014.10.002
dc.identifier.urihttps://hdl.handle.net/20.500.12511/906
dc.identifier.volume22
dc.identifier.wosqualityQ2
dc.indekslendigikaynakWeb of Science
dc.indekslendigikaynakScopus
dc.indekslendigikaynakPubMed
dc.language.isoen
dc.publisherElsevier Ltd
dc.relation.ispartofBioorganic and Medicinal Chemistryen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanı
dc.rightsinfo:eu-repo/semantics/embargoedAccess
dc.subject1,2,4-Triazine
dc.subjectAntiproliferative Activity
dc.subjectApoptosis
dc.subjectBreast Cancer
dc.subjectPiperazine Amide
dc.subjectXTT Method
dc.titleIn vitro antitumor activity evaluation of some 1,2,4-triazine derivatives bearing piperazine amide moiety against breast cancer cells
dc.typeArticle

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