Characterization of speech and language phenotype in the 8p23.1 syndrome

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dc.contributor.authorKarsan, Çağdaş
dc.contributor.authorOcak, Feyzanur
dc.contributor.authorBulut, Talat
dc.date.accessioned2025-11-16T08:41:32Z
dc.date.available2025-11-16T08:41:32Z
dc.date.issued2024
dc.departmentİstanbul Medipol Üniversitesi, Sağlık Bilimleri Fakültesi, Dil ve Konuşma Terapisi Bölümü
dc.description.abstractThe 8p23.1 duplication syndrome is a rare genetic condition with an estimated prevalence rate of 1 out of 58,000. Although the syndrome was associated with speech and language delays, a comprehensive assessment of speech and language functions has not been undertaken in this population. To address this issue, the present study reports rigorous speech and language, in addition to oral-facial and developmental, assessment of a 50-month-old Turkish-speaking boy who was diagnosed with the 8p23.1 duplication syndrome. Standardized tests of development, articulation and phonology, receptive and expressive language and a language sample analysis were administered to characterize speech and language skills in the patient. The language sample was obtained in an ecologically valid, free play and conversation context. The language sample was then analyzed and compared to a database of age-matched typically-developing children (n = 33) in terms of intelligibility, morphosyntax, semantics/vocabulary, discourse, verbal facility and percentage of errors at word and utterance levels. The results revealed mild to severe problems in articulation and phonology, receptive and expressive language skills, and morphosyntax (mean length of utterance in morphemes). Future research with larger sample sizes and employing detailed speech and language assessment is needed to delineate the speech and language profile in individuals with the 8p23.1 duplication syndrome, which will guide targeted speech and language interventions.
dc.description.sponsorshipTürkiye Bilimsel ve Teknolojik Araştırma Kurumu (TÜBİTAK)
dc.identifier.citationKarsan, Ç., Ocak, F. ve Bulut, T. (2024). Characterization of speech and language phenotype in the 8p23.1 syndrome. European Child and Adolescent Psychiatry, 33(10), 3671-3678. http://dx.doi.org/10.1007/s00787-024-02448-0
dc.identifier.doi10.1007/s00787-024-02448-0
dc.identifier.endpage3678
dc.identifier.issn1018-8827
dc.identifier.issn1435-165X
dc.identifier.issue10
dc.identifier.pmid38671247
dc.identifier.scopus2-s2.0-85191763867
dc.identifier.scopusqualityQ1
dc.identifier.startpage3671
dc.identifier.urihttp://dx.doi.org/10.1007/s00787-024-02448-0
dc.identifier.urihttps://hdl.handle.net/20.500.12511/13203
dc.identifier.volume33
dc.identifier.wosWOS:001208715600003
dc.identifier.wosqualityQ1
dc.indekslendigikaynakWeb of Science
dc.indekslendigikaynakScopus
dc.indekslendigikaynakPubMed
dc.institutionauthorBulut, Talat
dc.institutionauthorid0000-0003-0904-9399
dc.language.isoen
dc.relation.ispartofEuropean Child and Adolescent Psychiatry
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanı
dc.rightsinfo:eu-repo/semantics/openAccess
dc.rightsAttribution 4.0 International
dc.rights.urihttps://creativecommons.org/licenses/by/4.0/
dc.subject8p23.1 Duplication Syndrome
dc.subjectLanguage
dc.subjectSpeech
dc.titleCharacterization of speech and language phenotype in the 8p23.1 syndrome
dc.typeArticle

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