Systematic evolution of ligands by exponential enrichment for aptamer selection

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dc.authorid0000-0002-1677-644X
dc.contributor.authorYüce, Meral
dc.contributor.authorKurt, Hasan
dc.contributor.authorHussain, Babar
dc.contributor.authorBudak, Hikmet
dc.date.accessioned10.07.201910:49:13
dc.date.accessioned2019-07-10T19:38:13Z
dc.date.available10.07.201910:49:14
dc.date.available2019-07-10T19:38:13Z
dc.date.issued2018
dc.departmentİstanbul Medipol Üniversitesi, Mühendislik ve Doğa Bilimleri Fakültesi, Biyomedikal Mühendisliği Bölümü
dc.description.abstractDiscovery of aptamers and developments in the field of nanotechnology has made a significant contribution to the field of biosensing. Nanomaterials with various physical, optic, and electronic properties have been functionalized with aptamers, which are the synthetic counterparts of the conventional antibodies, to be used as more stable and cost-effective affinity probes for the detection of target molecules ranging from small ions, disease biomarkers, cell surfaces, microorganisms, and hazardous materials to food-borne allergens and pathogens. In this chapter, we described the fundamental methodology for in vitro aptamer selection, known as systematic evolution of ligands by exponential enrichment, with recent examples from the literature. We also provide the audience with graphical abstracts and illustrations for a better understanding of the aptamer selection concept.
dc.identifier.citationYüce, M., Kurt, H., Hussain, B. ve Budak, H. (2018). Systematic evolution of ligands by exponential enrichment for aptamer selection. Biomedical Applications of Functionalized Nanomaterials: Concepts, Development and Clinical Translation içinde (211-243. ss.). Elsevier. https://dx.doi.org/10.1016/B978-0-323-50878-0.00008-2
dc.identifier.doi10.1016/B978-0-323-50878-0.00008-2
dc.identifier.endpage243
dc.identifier.isbn9780323508797
dc.identifier.isbn9780323508780en_US
dc.identifier.scopusqualityN/A
dc.identifier.startpage211
dc.identifier.urihttps://hdl.handle.net/20.500.12511/1556
dc.identifier.urihttps://dx.doi.org/10.1016/B978-0-323-50878-0.00008-2
dc.indekslendigikaynakScopus
dc.language.isoen
dc.publisherElsevier
dc.relation.ispartofBiomedical Applications of Functionalized Nanomaterials: Concepts, Development and Clinical Translationen_US
dc.relation.publicationcategoryKitap Bölümü - Uluslararası
dc.rightsinfo:eu-repo/semantics/embargoedAccess
dc.subjectAptamer
dc.subjectBiosensing
dc.subjectNext-Generation Sequencing
dc.subjectOligonucleotide
dc.subjectPost-SELEX Modification
dc.subjectSELEX
dc.titleSystematic evolution of ligands by exponential enrichment for aptamer selection
dc.typeBook Chapter

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