Synthesis and anti-cancer activity evaluation of new aurone derivatives

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dc.contributor.authorDemirayak, Şeref
dc.contributor.authorYurttaş, Leyla
dc.contributor.authorGündoğdu Karaburun, Nalan
dc.contributor.authorKaraburun, Ahmet Çağrı
dc.contributor.authorKayagil, İsmail
dc.date.accessioned10.07.201910:49:13
dc.date.accessioned2019-07-10T19:58:05Z
dc.date.available10.07.201910:49:13
dc.date.available2019-07-10T19:58:05Z
dc.date.issued2015
dc.departmentİstanbul Medipol Üniversitesi, Eczacılık Fakültesi, Eczacılık Meslek Bilimleri Bölümü, Farmasötik Kimya Ana Bilim Dalı
dc.descriptionWOS: 000361328700014
dc.descriptionPubMed ID: 25716125
dc.description.abstractIn this study, we have synthesized 2-[3-or 4-(2-aryl-2-oxoethoxy) arylidene] benzofuran-3-one derivatives (D1-D38) and evaluated their anti-cancer activities. The final compounds were obtained in multistep synthesis reactions using benzofuranon-3-one derivatives (A1-A4, B) as starting materials which were gained in various synthetic ways. Aurone derivatives (C1-C10) were acquired with the condensation reaction of these starting materials and 3-/4-hydroxybenzaldehyde which were then reacted with a-bromoacetophenones to get final compounds. The anti-cancer activity of the selected compounds was performed by National Cancer Institute (NCI), USA against 60 human tumor cell lines derived from nine neoplastic diseases. Compounds exhibited anti-cancer activity in varying ratios.
dc.description.sponsorshipAnadolu University, Turkey (BAP) [050301]en_US
dc.description.sponsorshipThis work was supported by Anadolu University, Turkey (BAP Project No: 050301). The authors report no conflicts of interest.en_US
dc.identifier.citationDemirayak, Ş., Yurttaş, L., Gündoğdu Karaburun, N., Karaburun, A. Ç. ve Kayagil, İ. (2015). Synthesis and anti-cancer activity evaluation of new aurone derivatives. Journal of Enzyme Inhibition and Medicinal Chemistry, 30(5), 816-825. https://dx.doi.org/10.3109/14756366.2014.976568
dc.identifier.doi10.3109/14756366.2014.976568
dc.identifier.endpage825
dc.identifier.issn1475-6366
dc.identifier.issn1475-6374
dc.identifier.issue5
dc.identifier.scopusqualityQ1
dc.identifier.startpage816
dc.identifier.urihttps://dx.doi.org/10.3109/14756366.2014.976568
dc.identifier.urihttps://hdl.handle.net/20.500.12511/3103
dc.identifier.volume30
dc.identifier.wosqualityQ1
dc.indekslendigikaynakWeb of Science
dc.indekslendigikaynakScopus
dc.indekslendigikaynakPubMed
dc.language.isoen
dc.publisherTaylor and Francis
dc.relation.ispartofJournal of Enzyme Inhibition and Medicinal Chemistryen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanı
dc.rightsinfo:eu-repo/semantics/openAccess
dc.subjectAnti-Cancer Activity
dc.subjectAurone
dc.subjectBenzofuranone
dc.subjectNCI
dc.subjectSynthesis
dc.titleSynthesis and anti-cancer activity evaluation of new aurone derivatives
dc.typeArticle

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