Evaluation of the antidiabetic property of capparis ovata desf. Var. Palaestina zoh. Extracts using in vivo and in vitro approaches

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dc.authorid0000-0001-7706-6452
dc.authorid0000-0002-8084-7855
dc.contributor.authorOkur, Mehmet Evren
dc.contributor.authorÇiçek Polat, Derya
dc.contributor.authorÖzbek, Hanefi
dc.contributor.authorYılmaz, Sezen
dc.contributor.authorYoltaş, Ayşegül
dc.contributor.authorArslan, Rana
dc.date.accessioned10.07.201910:49:13
dc.date.accessioned2019-07-10T19:52:02Z
dc.date.available10.07.201910:49:13
dc.date.available2019-07-10T19:52:02Z
dc.date.issued2018
dc.departmentİstanbul Medipol Üniversitesi, Eczacılık Fakültesi, Eczacılık Meslek Bilimleri Bölümü, Farmakoloji Ana Bilim Dalı
dc.departmentİstanbul Medipol Üniversitesi, Tıp Fakültesi, Dahili Tıp Bilimleri Bölümü, Tıbbi Farmakoloji Ana Bilim Dalı
dc.descriptionWOS: 000445417300007
dc.descriptionPubMed ID: 29595118
dc.description.abstractBackground and Objective: This paper is focused on evaluating the various biological activities of C. ovata var. palaestina extracts which could beneficially influence diabetes and its complications. Methods: Alloxan-induced diabetic BALB-c mice were administered intraperitoneally with 100, 300, 500mg/kg doses of ethanol and aqueous extracts of buds and fruits. Furthermore, HPLC, phenolic and flavonoid compounds analysis, ABTS and DPPH free radical scavenging activity, anti-inflammatory activity, agar well diffusion and MIC tests were carried out. Results: Fruit-aqueous; 100mg/kg, 300mg/kg and bud-aqueous; 500mg/kg extracts showed significant hypoglycemic activity. All extracts indicated important antioxidant activity, however, bud-aqueous extract demonstrated the most potent activity. HPLC study exhibited that rutin is found in high amounts in bud-aqueous and bud-ethanol extracts. Furthermore, the bud-aqueous extract depicted stronger and broader antimicrobial activity than other extracts. Fruit-ethanol and bud-ethanol extracts denoted the most potent anti-inflammatory effect even though this effect was significantly shown by all extracts. Finally, high levels of phenolic and flavonoid content were involved in all extracts, but the highest levels were found in fruit-ethanol and bud-ethanol extracts. Conclusion: The results showed that extracts which indicated hypoglycemic, antioxidant, anti-inflammatory, antimicrobial activities may provide a valuable contribution to the management of diabetes and its complications.
dc.identifier.citationOkur, M. E., Çiçek Polat, D., Özbek, H., Yılmaz, S., Yoltaş, A. ve Arslan, R. (2018). Evaluation of the antidiabetic property of capparis ovata desf. Var. Palaestina zoh. Extracts using in vivo and in vitro approaches. Endocrine Metabolic & Immune Disorders-Drug Targets, 18(5), 489-501. https://dx.doi.org/10.2174/1871530318666180328110524
dc.identifier.doi10.2174/1871530318666180328110524
dc.identifier.endpage501
dc.identifier.issn1871-5303
dc.identifier.issn2212-3873
dc.identifier.issue5
dc.identifier.scopusqualityQ3
dc.identifier.startpage489
dc.identifier.urihttps://dx.doi.org/10.2174/1871530318666180328110524
dc.identifier.urihttps://hdl.handle.net/20.500.12511/2330
dc.identifier.volume18
dc.identifier.wosqualityQ3
dc.indekslendigikaynakWeb of Science
dc.indekslendigikaynakScopus
dc.indekslendigikaynakPubMed
dc.language.isoen
dc.publisherBentham Science Publ Ltd
dc.relation.ispartofEndocrine Metabolic & Immune Disorders-Drug Targetsen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanı
dc.rightsinfo:eu-repo/semantics/closedAccess
dc.subjectDiabetes Mellitus
dc.subjectC. Ovata Var Palaestina
dc.subjectHypoglycemic Effect
dc.subjectAntioxidant
dc.subjectAntimicrobial
dc.subjectHyperglycemia
dc.titleEvaluation of the antidiabetic property of capparis ovata desf. Var. Palaestina zoh. Extracts using in vivo and in vitro approaches
dc.typeArticle

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