Procedural sedation protocols with or without ketamine in pediatric gastrointestinal endoscopy: A retrospective cohort study

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dc.authorid000-0003-4741-7877
dc.contributor.authorYalçın, Naime
dc.contributor.authorKamilçelebi, Nurdan
dc.contributor.authorŞahin, Ayça Sultan
dc.contributor.authorSandal, Barış
dc.contributor.authorDerbent, Abdurrahim
dc.contributor.authorSalihoğlu, Ziya
dc.date.accessioned2023-06-05T12:31:24Z
dc.date.available2023-06-05T12:31:24Z
dc.date.issued2023
dc.departmentİstanbul Medipol Üniversitesi, Tıp Fakültesi, Cerrahi Tıp Bilimleri Bölümü, Anesteziyoloji ve Reanimasyon Ana Bilim Dalı
dc.description.abstractObjective: A considerable difference exists in pediatric endoscopy sedation practices with the optimal sedation protocol for gastrointestinal (GI) endoscopy a subject of controversy and to investigate the safety and efficacy of sedation protocols with or without ketamine in procedural sedation for pediatric GI endoscopy. Materials and Methods: A total of 78 pediatric patients who received sedation anesthesia for GI endoscopy were included in this retrospective study. Anesthesia parameters include duration time, doses of anesthetic agents, Ramsay sedation score, respiratory and hemodynamic parameters, recovery time, modified Aldrete recovery scores, and side effects. Study parameters were evaluated with respect to ketamine dose (no ketamine group (NKG), low-dose ketamine group (LDKG, ?0.75 mg/kg), and high-dose ketamine group (HDKG, ?1 mg/kg). Results: The upper GI endoscopy rate (58.12% vs. 90.0%, p=0.001) was significantly lower in LDKG versus HDKG. No significant changes were observed in blood pressure levels, oxygen saturation, or heart rate compared to baseline levels. No significant difference was noted between study groups in terms of recovery time, modified Aldrete recovery scores, and nausea/vomiting. Final Ramsay sedation scores were significantly higher in NKG (p<0.05) and LDKG (p<0.01) than in HDKG. Conclusion: Our findings indicate a favorable safety and efficacy profile for ketamine as a useful adjunct to procedural sedation for pediatric GI endoscopy, enabling better quality of sedation with a low risk of cardiorespiratory suppression, or serious complications.
dc.identifier.citationYalçın, N., Kamilçelebi, N., Şahin, A. S., Sandal, B., Derbent, A. ve Salihoğlu, Z. (2023). Procedural sedation protocols with or without ketamine in pediatric gastrointestinal endoscopy: A retrospective cohort study. Comprehensive Medicine, 15(2), 112-119. https://doi.org/10.14744/cm.2023.47965
dc.identifier.doi10.14744/cm.2023.47965
dc.identifier.endpage119
dc.identifier.issn2822-6771
dc.identifier.issue2
dc.identifier.startpage112
dc.identifier.trdizinid1178918
dc.identifier.urihttps://doi.org/10.14744/cm.2023.47965
dc.identifier.urihttps://hdl.handle.net/20.500.12511/11026
dc.identifier.volume15
dc.indekslendigikaynakTR-Dizin
dc.institutionauthorKamilçelebi, Nurdan
dc.language.isoen
dc.publisherKare Publishing
dc.relation.ispartofComprehensive Medicineen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanı
dc.rightsAttribution-NonCommercial 4.0 International*
dc.rightsinfo:eu-repo/semantics/openAccess
dc.rights.urihttps://creativecommons.org/licenses/by-nc/4.0/*
dc.subjectChildren
dc.subjectGastrointestinal Endoscopy
dc.subjectKetamine
dc.subjectPatient Safety
dc.titleProcedural sedation protocols with or without ketamine in pediatric gastrointestinal endoscopy: A retrospective cohort study
dc.typeArticle

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