Decoding the secrets of small extracellular vesicle communications: exploring the inhibition of vesicle-associated pathways and interception strategies for cancer treatment

Basit Öğe Kaydı
dc.contributor.authorShams, Shams G. E.
dc.contributor.authorOcampo, Ron Joseph
dc.contributor.authorRahman, Sanna
dc.contributor.authorMakhlouf, Maysoon M.
dc.contributor.authorAli, Jihad
dc.contributor.authorElnashar, Magdy M.
dc.contributor.authorEbrahim, Hassan L.
dc.contributor.authorAbd Elmageed, Zakaria Y.
dc.date.accessioned2024-06-27T11:40:31Z
dc.date.available2024-06-27T11:40:31Z
dc.date.issued2024
dc.departmentİstanbul Medipol Üniversitesi, Tıp Fakültesi
dc.description.abstractCancer disease is the second leading cause of death worldwide. In 2023, about 2 million new cancer cases and 609,820 cancer deaths are projected to occur in the United States. The driving forces of cancer progression and metastasis are widely varied and comprise multifactorial events. Although there is significant success in treating cancer, patients still present with tumors at advanced stages. Therefore, the discovery of novel oncologic pathways has been widely developed. Tumor cells communicate with each other through small extracellular vesicles (sEVs), which contribute to tumor-stromal interaction and promote tumor growth and metastasis. sEV-specific inhibitors are being investigated as a next-generation cancer therapy. A literature search was conducted to discuss different options for targeting sEV pathways in cancer cells. However, there are some challenges that need to be addressed in targeting sEVs: i) specificity and toxicity of sEV inhibitor, ii) targeted delivery of sEV inhibitors, iii) combination of sEV inhibitors with current standard chemotherapy to improve patients' clinical outcomes, and iv) data reproducibility and applicability at distinct levels of the disease. Despite these challenges, sEV inhibitors have immense potential for effectively treating cancer patients.
dc.identifier.citationShams, S. G. E., Ocampo, R. J., Rahman, S., Makhlouf, M. M., Ali, J., Elnashar, M. M. ... Abd Elmageed, Z. Y. (2024). Decoding the secrets of small extracellular vesicle communications: exploring the inhibition of vesicle-associated pathways and interception strategies for cancer treatment. American Journal of Cancer Research, 14(5), 1957-1980. http://dx.doi.org/10.62347/JWMX3035
dc.identifier.doi10.62347/JWMX3035
dc.identifier.endpage1980
dc.identifier.issn2156-6976
dc.identifier.issue5
dc.identifier.pmid38859839
dc.identifier.startpage1957
dc.identifier.urihttp://dx.doi.org/10.62347/JWMX3035
dc.identifier.urihttps://hdl.handle.net/20.500.12511/12661
dc.identifier.volume14
dc.identifier.wos001232018400023en_US
dc.identifier.wosqualityQ2
dc.indekslendigikaynakWeb of Science
dc.indekslendigikaynakPubMed
dc.institutionauthorAli, Jihad
dc.language.isoen
dc.relation.ispartofAmerican Journal of Cancer Researchen_US
dc.relation.publicationcategoryDiğer
dc.rightsinfo:eu-repo/semantics/openAccess
dc.subjectSmall Extracellular Vesicles
dc.subjectCancer Treatment
dc.subjectSev Inhibitors
dc.subjectClinical Applications
dc.titleDecoding the secrets of small extracellular vesicle communications: exploring the inhibition of vesicle-associated pathways and interception strategies for cancer treatment
dc.typeOther

Dosyalar

Orijinal paket
Listeleniyor 1 - 1 / 1
Küçük Resim
İsim:
Ali-Jihad-2024.pdf
Boyut:
1.31 MB
Biçim:
Adobe Portable Document Format
Açıklama:
Tam Metin / Full Text
İndir
Lisans paketi
Listeleniyor 1 - 1 / 1
Küçük Resim Yok
İsim:
license.txt
Boyut:
1.44 KB
Biçim:
Item-specific license agreed upon to submission
Açıklama:
İndir

Koleksiyon

Diğer Yayınlar Koleksiyonu
PubMed İndeksli Yayınlar Koleksiyonu
WoS İndeksli Yayınlar Koleksiyonu