Investigation of the effects of tigecycline, a semi-synthetic derivative of minocycline, on chondrocyte cultures
| dc.authorid | 0000-0003-2003-6337 | |
| dc.authorid | 0000-0002-8084-7855 | |
| dc.contributor.author | Kaya, Yasin Emre | |
| dc.contributor.author | Karaarslan, Numan | |
| dc.contributor.author | Yılmaz, İbrahim | |
| dc.contributor.author | Yaşar Şirin, Duygu | |
| dc.contributor.author | Yaman, Onur | |
| dc.contributor.author | Özbek, Hanefi | |
| dc.contributor.author | Ateş, Özkan | |
| dc.date.accessioned | 2021-02-05T12:45:03Z | |
| dc.date.available | 2021-02-05T12:45:03Z | |
| dc.date.issued | 2020 | |
| dc.department | İstanbul Medipol Üniversitesi, Tıp Fakültesi, Dahili Tıp Bilimleri Bölümü, Tıbbi Farmakoloji Ana Bilim Dalı | |
| dc.description.abstract | Abstract Aim: Although antibiotics are generally well-tolerated, they may have cytotoxic effects. The present randomized, double-blind, in vitro study aimed to investigate the effects of tigecycline on cartilage tissue cells and the extracellular matrix. Material and Methods: Cartilage tissues of patients (n = 8) were used for the preparation of primary cell cultures. Tigecycline-treated cell cultures served as the study group. Non-treated cell cultures served as the control group. Analyses were performed at 0, 24, 48, and 72 h in both groups. The results obtained were statistically evaluated. The alpha significance value was determined to be 0.05. Results: Proliferation remained unchanged in the tigecycline-treated cell cultures. The gene expressions of the markers involved in anabolic pathways increased in the tigecycline-treated cell cultures. The results obtained were statistically significant (P < 0.05). Conclusion: Although tigecycline had no toxic effect on the chondrocyte cell cultures and caused no damage to the extracellular matrix, the present study was performed in an in vitro environment. | |
| dc.identifier.citation | Kaya, Y. E., Karaarslan, N., Yılmaz, İ., Yaşar Şirin, D., Yaman, O., Özbek, H. ... Ateş, Ö. (2020). Investigation of the effects of tigecycline, a semi-synthetic derivative of minocycline, on chondrocyte cultures. Annals of Medical Research, 27(4), 1082-1087. https://doi.org/10.5455/annalsmedres.2019.11.780 | |
| dc.identifier.doi | 10.5455/annalsmedres.2019.11.780 | |
| dc.identifier.endpage | 1087 | |
| dc.identifier.issn | 2636-7688 | |
| dc.identifier.issue | 4 | |
| dc.identifier.startpage | 1082 | |
| dc.identifier.uri | https://doi.org/10.5455/annalsmedres.2019.11.780 | |
| dc.identifier.uri | https://hdl.handle.net/20.500.12511/6533 | |
| dc.identifier.volume | 27 | |
| dc.indekslendigikaynak | TR-Dizin | |
| dc.language.iso | en | |
| dc.publisher | Annals of Medical Research Publishing Inc | |
| dc.relation.ispartof | Annals of Medical Research | en_US |
| dc.relation.publicationcategory | Makale - Ulusal Hakemli Dergi - Kurum Öğretim Elemanı | |
| dc.rights | info:eu-repo/semantics/openAccess | |
| dc.subject | Chondroadherin Gene | |
| dc.subject | Cartilage Oligomeric Protein | |
| dc.subject | Interleukin-1beta | |
| dc.subject | Matrix Metalloproteinase | |
| dc.subject | Primary Chondrocyte Culture | |
| dc.subject | Tigecycline | |
| dc.title | Investigation of the effects of tigecycline, a semi-synthetic derivative of minocycline, on chondrocyte cultures | |
| dc.type | Article |
