Panax ginseng extract ameliorates methotrexate-induced multi-organ damage via the regulation of oxidative stress

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dc.authorid0000-0002-5532-2395
dc.contributor.authorMacit, Çağlar
dc.contributor.authorEde Pazarbaşı, Seren
dc.contributor.authorYılmaz Karaoğlu, Sümeyye
dc.contributor.authorTunali Akbay, Tuğba
dc.contributor.authorKarakaya Çimen, Fatma Bedia
dc.contributor.authorErcan, Feriha
dc.contributor.authorŞener, Göksel
dc.date.accessioned2023-10-03T06:54:16Z
dc.date.available2023-10-03T06:54:16Z
dc.date.issued2023
dc.departmentİstanbul Medipol Üniversitesi, Eczacılık Fakültesi, Eczacılık Meslek Bilimleri Bölümü, Farmakoloji Ana Bilim Dalı
dc.description.abstractOxidative damage plays an important role in organ toxicities caused by methotrexate (MTX). This study aimed to determine the antioxidant effects of Panax ginseng (PxG) extract against MTX-induced liver, lung, ileum and kidney damage. Twenty-four Sprague Dawley male rats (weight 250-300 g) were used in the study. The animals were randomly separated into three groups: a) Control, b) MTX-treated (MTX) and c) MTX+PxG-treated (MTX+PxG) groups. MTX was administered intraperitoneally at 20 mg/kg, as a single dose to MTX and MTX+PxG groups. PxG was administered orally at 100 mg/kg to the MTX+PxG group for five days. Saline was given to the control and MTX groups for 5 days. At the end of the experiment, liver, lung, ileum, and kidney samples were obtained. Malondialdehyde (MDA) and glutathione (GSH) levels, superoxide dismutase (SOD), glutathione-S-transferase (GST) and tissue factor (TF) activities were determined in all tissues. In addition, histological examinations were done through light microscopy. GraphPad Prism 5v. was used for statistics, and p[removed].
dc.identifier.citationMacit, Ç., Ede Pazarbaşı, S., Yılmaz Karaoğlu, S., Tunali Akbay, T., Karakaya Çimen, F. B., Ercan, F. ... Şener, G. (2023). Panax ginseng extract ameliorates methotrexate-induced multi-organ damage via the regulation of oxidative stress. Journal of Research in Pharmacy, 27(5), 1974-1988. https://doi.org/10.29228/jrp.477
dc.identifier.doi10.29228/jrp.477
dc.identifier.endpage1988
dc.identifier.issn2630-6344
dc.identifier.issue5
dc.identifier.scopus2-s2.0-85171323419
dc.identifier.scopusqualityQ3
dc.identifier.startpage1974
dc.identifier.urihttps://doi.org/10.29228/jrp.477
dc.identifier.urihttps://hdl.handle.net/20.500.12511/11517
dc.identifier.volume27
dc.identifier.wos001069183100019en_US
dc.identifier.wosqualityN/A
dc.indekslendigikaynakWeb of Science
dc.indekslendigikaynakScopus
dc.institutionauthorMacit, Çağlar
dc.language.isoen
dc.publisherMarmara University
dc.relation.ispartofJournal of Research in Pharmacyen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanı
dc.rightsinfo:eu-repo/semantics/embargoedAccess
dc.subjectAntioxidant Activity
dc.subjectIleum
dc.subjectKidney
dc.subjectLiver
dc.subjectLung
dc.subjectMethotrexate
dc.subjectPanax Ginseng Extract
dc.titlePanax ginseng extract ameliorates methotrexate-induced multi-organ damage via the regulation of oxidative stress
dc.typeArticle

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