The combined supplementation of omega-3 fatty acids and probiotics decreased the levels of serum polyamines in experimental colitis

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dc.authorid0000-0003-1420-0989
dc.contributor.authorYoldaş İlktaç, Havvanur
dc.contributor.authorBüyükuslu, Nihal
dc.contributor.authorParlayan, Cüneyd
dc.date.accessioned2023-03-31T08:30:48Z
dc.date.available2023-03-31T08:30:48Z
dc.date.issued2021
dc.departmentİstanbul Medipol Üniversitesi, Sağlık Bilimleri Fakültesi, Beslenme ve Diyetetik Bölümü
dc.description.abstractPolyamines play an important role in the maintenance of intestinal permeability. Therefore we aimed to determine the effects of probiotics and omega 3 fatty acids on serum polyamine levels in colitis. Fifty BALB/c mice were randomly grouped as normal, colitis with no treatment applied, colitis treated by probiotics (VSL#3), colitis treated by omega-3, and colitis treated by both probiotics and omega-3. Experimental colitis was induced by injection of 200 mg/kg 2,4-Dinitrobenzenesulfonic acid (DNBS). The probiotic and the omega-3 fatty acid supplements were applied daily by oral gavage. Serum polyamine levels were measured with high performance liquid chromatography (HPLC). In each group, the levels of serum polyamines are the highest in spermidine and the least in spermine. Bowel inflammation in experimentally induced colitis mice resulted in lower serum polyamine concentrations. In probiotic and omega 3 fatty acid supplemented group significant decreases were observed for spermine and spermidine (p<0.001), while no significant changes were obtained for putrescine. Combined supplementation of probiotics and omega-3 fatty acids for 10 days in colitis mice significantly decreased the serum levels of spermine and spermidine.
dc.identifier.citationYoldaş İlktaç, H., Büyükuslu, N. ve Parlayan, C. (2021). The combined supplementation of omega-3 fatty acids and probiotics decreased the levels of serum polyamines in experimental colitis. Food and Health, 7(4), 279-285. https://dx.doi.org/10.3153/FH21029
dc.identifier.doi10.3153/FH21029
dc.identifier.endpage285
dc.identifier.issn2602-2834
dc.identifier.issue4
dc.identifier.startpage279
dc.identifier.trdizinid498420
dc.identifier.urihttps://dx.doi.org/10.3153/FH21029
dc.identifier.urihttps://hdl.handle.net/20.500.12511/10784
dc.identifier.volume7
dc.indekslendigikaynakTR-Dizin
dc.institutionauthorBüyükuslu, Nihal
dc.language.isoen
dc.relation.ispartofFood and Healthen_US
dc.relation.publicationcategoryMakale - Ulusal Hakemli Dergi - Kurum Öğretim Elemanı
dc.rightsAttribution 4.0 International*
dc.rightsinfo:eu-repo/semantics/openAccess
dc.rights.urihttps://creativecommons.org/licenses/by/4.0/*
dc.subjectColitis
dc.subjectInflammatory Bowel Disease
dc.subjectOmega-3 Fatty Acids
dc.subjectProbiotics
dc.subjectPolyamines
dc.titleThe combined supplementation of omega-3 fatty acids and probiotics decreased the levels of serum polyamines in experimental colitis
dc.typeArticle

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