Comparison of the rates for reaching the blastocyst stage between normal and abnormal pronucleus embryos monitored by a time-lapse system in IVF patients

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dc.authorid0000-0001-6440-0984
dc.contributor.authorUzun, Kübra Nur
dc.contributor.authorCıncık, Mehmet
dc.contributor.authorSelam, Belgin
dc.contributor.authorTakmaz, Özgüç
dc.contributor.authorUyar, Esra
dc.date.accessioned2021-06-17T06:24:38Z
dc.date.available2021-06-17T06:24:38Z
dc.date.issued2021
dc.departmentİstanbul Medipol Üniversitesi, Sağlık Bilimleri Enstitüsü, Histoloji ve Embriyoloji Ana Bilim Dalı
dc.description.abstractObjective: To compare the rates of blastocyst stage development between embryos fertilized after one (MPN) or more than two pronucleus (PN) (3PN, 4PN-multiPN) with those after 2PN in the same patients. Material and Methods: The embryos of patients who had both abnormal PN (MPN, 3PN or 4PN) and normal fertilized (2PN) embryos after intracytoplasmic sperm injection (ICSI) fertilization, were followed with a time-lapse system following the ICSI procedure. The rates of reaching the blastocyst stage were compared between normal and abnormally fertilized embryos. Results: One thousand eight hundred and twenty oocytes were collected from 140 patients and 1280 (70.3%) of them were fertilized. MPN, 2PN and 3PN, 4PN (multiPN) ratios of the embryos in the pronuclear stage were 11.4%, 83.13% and 5.47%, respectively. The rates of reaching the blastocyst stage among these embryos were 17.1%, 60.8% and 42.8% for MPN, 2PN and multiPN, respectively. The proportion reaching blastocyst development was significantly higher following 2PN compared to those after MPN and multiPN (p<0.05). Embryos developing after multiPN had significantly higher rates of reaching the blastocyst stage compared to those after MPN (p<0.01). Conclusion: The majority of abnormally pronucleated embryos arrest without reaching the blastocyst stage. MultiPN embryos have a higher rate of blastocyst development than MPN embryos.
dc.identifier.citationUzun, K. N., Cıncık, M., Selam, B., Takmaz, Ö. ve Uyar, E. (2021). Comparison of the rates for reaching the blastocyst stage between normal and abnormal pronucleus embryos monitored by a time-lapse system in IVF patients. Journal of the Turkish-German Gynecological Association, 22(2), 120-126. https://dx.doi.org/10.4274/jtgga.galenos.2021.2020.0033
dc.identifier.doi10.4274/jtgga.galenos.2021.2020.0033
dc.identifier.endpage126
dc.identifier.issn1309-0399
dc.identifier.issn1309-0380
dc.identifier.issue2
dc.identifier.scopusqualityQ3
dc.identifier.startpage120
dc.identifier.urihttps://dx.doi.org/10.4274/jtgga.galenos.2021.2020.0033
dc.identifier.urihttps://hdl.handle.net/20.500.12511/7204
dc.identifier.volume22
dc.identifier.wosqualityN/A
dc.indekslendigikaynakWeb of Science
dc.indekslendigikaynakScopus
dc.indekslendigikaynakTR-Dizin
dc.indekslendigikaynakPubMed
dc.language.isoen
dc.publisherGalenos Yayıncılık
dc.relation.ispartofJournal of the Turkish-German Gynecological Associationen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - İdari Personel ve Öğrenci
dc.rightsinfo:eu-repo/semantics/openAccess
dc.subjectBlastocyst
dc.subjectICSI
dc.subjectMPN
dc.subjectmultiPN
dc.subjectTime-Lapse
dc.titleComparison of the rates for reaching the blastocyst stage between normal and abnormal pronucleus embryos monitored by a time-lapse system in IVF patients
dc.typeArticle

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