Frozen embryo transfer prevents the detrimental effect of high estrogen on endometrium receptivity

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dc.contributor.authorErşahin, Aynur Adeviye
dc.contributor.authorAcet, Mustafa
dc.contributor.authorErşahin, Suat Süphan
dc.contributor.authorDokuzeylül Güngör, Nur
dc.date.accessioned10.07.201910:49:13
dc.date.accessioned2019-07-10T20:01:33Z
dc.date.available10.07.201910:49:13
dc.date.available2019-07-10T20:01:33Z
dc.date.issued2017
dc.departmentİstanbul Medipol Üniversitesi, Tıp Fakültesi, Cerrahi Tıp Bilimleri Bölümü, Kadın Hastalıkları ve Doğum Ana Bilim Dalı
dc.descriptionWOS: 000398542000008
dc.descriptionPubMed ID: 28506949
dc.description.abstractObjective: To investigate whether serum levels of estradiol affect reproductive outcomes of normoresponder women undergoing fresh embryo transfer (ET) versus frozen-thawed ET (FET). Material and Methods: Two hundred fifty-five normoresponder women underwent fresh ET in their first or second in vitro fertilization cycle. Ninety-two women with negative pregnacy test results underwent FET. Clinical and ongoing pregnancy rates, implantation, and live birth rates of women undergoing fresh ET versus FET were compared. Results: One hundred forty-seven (57.65%) out of the 255 normoresponder women receiving FET had positive beta-human chorionic gonadotrophin (hCG) results. The remaining 108 women had negative beta-hCG results. The clinical pregnancy rates of the fresh ET group were found as 55.69% (n=142). Ninety-two of the 108 women with failed pregnancies underwent FET; 72.83% had positive beta-hCG results (n=67), and 70.65% had clinical pregnancy (n=65). Both biochemical and clinical pregnancy rates of women undergoing FET increased significantly (p<0.012 and p<0.013, respectively). Ongoing pregnancy (60.87% vs. 52.94%) and live birth rates (59.87% vs. 48.63%) were similar in both fresh and FET groups. Serum E2 levels of women who failed to conceive were significantly higher than those women did conceive. Serum progesterone levels of women who conceived versus those that did not were similar. Conclusion: The detrimental effect of high serum estradiol levels on endometrial receptivity could be prevented by FET.
dc.identifier.citationErşahin, A. A., Acet, M., Erşahin, S. S. ve Dokuzeylül Güngör, N. (2017). Frozen embryo transfer prevents the detrimental effect of high estrogen on endometrium receptivity. Journal of the Turkish-German Gynecological Association, 18(1), 38-42. https://dx.doi.org/10.4274/jtgga.2016.0186
dc.identifier.doi10.4274/jtgga.2016.0186
dc.identifier.endpage42
dc.identifier.issn1309-0399
dc.identifier.issn1309-0380
dc.identifier.issue1
dc.identifier.scopusqualityQ3
dc.identifier.startpage38
dc.identifier.urihttps://dx.doi.org/10.4274/jtgga.2016.0186
dc.identifier.urihttps://hdl.handle.net/20.500.12511/3335
dc.identifier.volume18
dc.identifier.wosqualityN/A
dc.indekslendigikaynakWeb of Science
dc.indekslendigikaynakScopus
dc.indekslendigikaynakTR-Dizin
dc.indekslendigikaynakPubMed
dc.language.isoen
dc.publisherGalenos Yayıncılık
dc.relation.ispartofJournal of the Turkish-German Gynecological Associationen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanı
dc.rightsinfo:eu-repo/semantics/openAccess
dc.subjectFrozen Embryo Transfer
dc.subjectFresh Embryo Transfer
dc.subjectClinical Pregnancy Rates
dc.subjectSerum Estradiol
dc.subjectSerum Progesterone
dc.titleFrozen embryo transfer prevents the detrimental effect of high estrogen on endometrium receptivity
dc.typeArticle

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