Radiological features characterising indeterminate testes masses: a systematic review and meta-analysis

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dc.authorid0000-0003-0906-4417
dc.contributor.authorAger, Michael
dc.contributor.authorDonegan, Sarah
dc.contributor.authorBoeri, Luca
dc.contributor.authorde Castro, Javier Mayor
dc.contributor.authorDonaldson, James F.
dc.contributor.authorOmar, Muhammad Imran
dc.contributor.authorDimitropoulos, Konstantinos
dc.contributor.authorTharakan, Tharu
dc.contributor.authorJanisch, Florian
dc.contributor.authorMuilwijk, Tim
dc.contributor.authorYuan, Cathy
dc.contributor.authorTudur-Smith, Catrin
dc.contributor.authorNijman, Rien J. M.
dc.contributor.authorRadmayr, Christian
dc.contributor.authorSalonia, Andrea
dc.contributor.authordel Pilar Laguna Pes, Maria
dc.contributor.authorMinhas, Suks
dc.date.accessioned2023-09-19T06:51:02Z
dc.date.available2023-09-19T06:51:02Z
dc.date.issued2023
dc.departmentİstanbul Medipol Üniversitesi, Tıp Fakültesi, Cerrahi Tıp Bilimleri Bölümü, Üroloji Ana Bilim Dalı
dc.departmentİstanbul Medipol Üniversitesi, Uluslararası Tıp Fakültesi, Cerrahi Tıp Bilimleri Bölümü, Üroloji Ana Bilim Dalı
dc.description.abstractContext: The use of scrotal ultrasonography (SUS) has increased the detection rate of indeterminate testicular masses. Defining radiological characteristics that identify malignancy may reduce the number of men undergoing unnecessary radical orchidectomy. Objective: To define which SUS or scrotal magnetic resonance imaging (MRI) characteristics can predict benign or malignant disease in pre- or post-pubertal males with indeterminate testicular masses. Evidence Acquisition: This systematic review was conducted in accordance with Cochrane Collaboration guidance. Medline, Embase, Cochrane controlled trials and systematic reviews databases were searched from (1970 to 26 March 2021). Benign and malignant masses were classified using the reported reference test: i.e., histopathology, or 12 months progression-free radiological surveillance. Risk of bias was assessed using the Quality Assessment of Diagnostic Accuracy Studies-2 tool (QUADAS-2). Evidence Synthesis: A total of 32 studies were identified, including 1692 masses of which 28 studies and 1550 masses reported SUS features, four studies and 142 masses reported MRI features. Meta-analysis of different SUS (B-mode) values in post-pubertal men demonstrated that a size of ?0.5 cm had a significantly lower odds ratio (OR) of malignancy compared to masses of >0.5 cm (P < 0.001). Comparison of masses of 0.6–1.0 cm and masses of >1.5 cm also demonstrated a significantly lower OR of malignancy (P = 0.04). There was no significant difference between masses of 0.6–1.0 and 1.1–1.5 cm. SUS in post-pubertal men also had a statistically significantly lower OR of malignancy for heterogenous masses vs homogenous masses (P = 0.04), hyperechogenic vs hypoechogenic masses (P < 0.01), normal vs increased enhancement (P < 0.01), and peripheral vs central vascularity (P < 0.01), respectively. There were limited data on pre-pubertal SUS, pre-pubertal MRI and post-pubertal MRI. Conclusions: This meta-analysis identifies radiological characteristics that have a lower OR of malignancy and may be of value in the management of the indeterminate testis mass.
dc.identifier.citationAger, M., Donegan, S., Boeri, L., de Castro, J. M., Donaldson, J. F., Omar, M. I. ... Minhas, S. (2023). Radiological features characterising indeterminate testes masses: a systematic review and meta-analysis. BJU International, 131(3), 288-300. https://dx.doi.org/10.1111/bju.15869
dc.identifier.doi10.1111/bju.15869
dc.identifier.endpage300
dc.identifier.issn1464-4096
dc.identifier.issn1464-410X
dc.identifier.issue3
dc.identifier.pmid35980855
dc.identifier.scopus2-s2.0-85139397044
dc.identifier.scopusqualityQ1
dc.identifier.startpage288
dc.identifier.urihttps://dx.doi.org/10.1111/bju.15869
dc.identifier.urihttps://hdl.handle.net/20.500.12511/11454
dc.identifier.volume131
dc.identifier.wos000865293700001en_US
dc.identifier.wosqualityQ1
dc.indekslendigikaynakWeb of Science
dc.indekslendigikaynakScopus
dc.indekslendigikaynakPubMed
dc.institutionauthordel Pilar Laguna Pes, Maria
dc.language.isoen
dc.publisherWiley
dc.relation.ispartofBJU Internationalen_US
dc.relation.publicationcategoryDiğer
dc.rightsinfo:eu-repo/semantics/embargoedAccess
dc.subjectFocal Testicular Mass
dc.subjectIndeterminate Testicular Mass
dc.subjectMeta-Analysis
dc.subjectScrotal MRI
dc.subjectScrotal Ultrasound
dc.subjectSmall Testicular Mass
dc.subjectSystematic Review
dc.subjectTesticular Cancer
dc.subjectTestis
dc.titleRadiological features characterising indeterminate testes masses: a systematic review and meta-analysis
dc.typeReview Article

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