Opuntia ficus indica fruits ameliorate cisplatin-induced nephrotoxicity in mice
| dc.authorid | 0000-0003-2143-5268 | |
| dc.authorid | 0000-0002-3412-0807 | |
| dc.contributor.author | Okur, Mehmet Evren | |
| dc.contributor.author | Ayla, Şule | |
| dc.contributor.author | Karadağ, Ayşe Esra | |
| dc.contributor.author | Polat, Derya Çiçek | |
| dc.contributor.author | Demirci, Sibel | |
| dc.contributor.author | Seçkin, İsmail | |
| dc.date.accessioned | 2020-09-30T08:36:06Z | |
| dc.date.available | 2020-09-30T08:36:06Z | |
| dc.date.issued | 2020 | |
| dc.department | İstanbul Medipol Üniversitesi, Tıp Fakültesi, Temel Tıp Bilimleri Bölümü, Histoloji ve Embriyoloji Ana Bilim Dalı | |
| dc.department | İstanbul Medipol Üniversitesi, Eczacılık Fakültesi, Eczacılık Meslek Bilimleri Bölümü, Farmakognozi Ana Bilim Dalı | |
| dc.description.abstract | This study aims to determine the potential renal protective effects of Opuntia ficus-indica (L.) Miller (OFI) fruits against cisplatin-induced nephrotoxicity in mice. The antioxidant activity of OH methanol extract was calculated by 2,2-dipheny1-1-picrylhydrazyl (DPPH) and 2,2'-azino-bis-3-ethylbenzthiazoline6-sulfonic acid (ABTS) free radical scavenging assays. Furthermore, the LC-mass spectroscopy (MS) analysis of the OFI fruit extract was carried out. Mice were treated with OFI extract (250mg/kg) for 10d and injected with a single dose of cisplatin (20 mg/kg) on the 7th day. The blood samples were collected to measure blood urea nitrogen (BUN) and serum creatinine level on the 10th day. Their kidneys were removed for histopathological examination. The renal morphological alterations were assessed through the mesangial matrix index and transmission electron microscopy (TEM). The OH fruit extract showed significant in vitro antioxidant activity. In further, it was revealed that the cisplatin-induced nephrotoxicity in mice was ameliorated; this outcome was supported by both histological examination results and the depicted reduced levels of BUN and serum creatinine. The potent antioxidant compounds which were detected in the extract of OH fruits such as myricetin, quercetin, luteolin might be responsible for the observed renoprotective effect. The results clarified that the OFI fruit extract could ameliorate cisplatin-induced renal toxicity in mice via including antioxidant and renoprotective compounds. | |
| dc.identifier.citation | Okur, M. E., Ayla, Ş., Karadağ, A. E., Polat, D. Ç., Demirci, S. ve Seçkin, İ. (2020). Opuntia ficus indica fruits ameliorate cisplatin-induced nephrotoxicity in mice. Biological and Pharmaceutical Bulletin, 43(5), 831-838. https://dx.doi.org/10.1248/bpb.b19-01044 | |
| dc.identifier.doi | 10.1248/bpb.b19-01044 | |
| dc.identifier.endpage | 838 | |
| dc.identifier.issn | 0918-6158 | |
| dc.identifier.issue | 5 | |
| dc.identifier.scopusquality | Q2 | |
| dc.identifier.startpage | 831 | |
| dc.identifier.uri | https://dx.doi.org/10.1248/bpb.b19-01044 | |
| dc.identifier.uri | https://hdl.handle.net/20.500.12511/5891 | |
| dc.identifier.volume | 43 | |
| dc.identifier.wosquality | Q4 | |
| dc.indekslendigikaynak | Web of Science | |
| dc.indekslendigikaynak | Scopus | |
| dc.indekslendigikaynak | PubMed | |
| dc.language.iso | en | |
| dc.publisher | Pharmaceutical Society of Japan | |
| dc.relation.ispartof | Biological and Pharmaceutical Bulletin | en_US |
| dc.relation.publicationcategory | Makale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanı | |
| dc.rights | info:eu-repo/semantics/openAccess | |
| dc.subject | Cisplatin | |
| dc.subject | Nephrotoxicity | |
| dc.subject | Opuntia | |
| dc.subject | Methanol Extract | |
| dc.subject | Mouse | |
| dc.title | Opuntia ficus indica fruits ameliorate cisplatin-induced nephrotoxicity in mice | |
| dc.type | Article |
