Systematic evaluation of promising clinical trials-gene silencing for the treatment of glioblastoma

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dc.authorid0000-0003-2003-6337
dc.authorid0000-0002-8084-7855
dc.contributor.authorKaraarslan, Numan
dc.contributor.authorYılmaz, İbrahim
dc.contributor.authorÖzbek, Hanefi
dc.contributor.authorÇalışkan, Tezcan
dc.contributor.authorTopuk, Savaş
dc.contributor.authorYaşar Şirin, Duygu
dc.contributor.authorAteş, Özkan
dc.date.accessioned10.07.201910:49:13
dc.date.accessioned2019-07-10T20:04:10Z
dc.date.available10.07.201910:49:13
dc.date.available2019-07-10T20:04:10Z
dc.date.issued2019
dc.departmentİstanbul Medipol Üniversitesi, Tıp Fakültesi, Dahili Tıp Bilimleri Bölümü, Tıbbi Farmakoloji Ana Bilim Dalı
dc.descriptionWOS: 000466983900003
dc.descriptionPubMed ID: 29694664
dc.description.abstractAIM: To systematically investigate the role of artificial small interfering RNA (SiRNA) molecules in glioblastoma treatment and to give a detailed overview of the literature concerning studies performed in this field worldwide in the last 31 years. MATERIAL and METHODS: Articles about clinical trials conducted between December 1, 1949 and November 8, 2017, were identified from the Cochrane Collaboration, the Cochrane Library, Ovid MEDLINE, ProQuest, the National Library of Medicine, and PubMed electronic databases, using the terms "post transcriptional gene silencing," "small interfering RNA," "siRNA," and "glioblastoma," either individually or combined ("OR" and "AND"), without language and country restrictions. Articles that met the examination criteria were included in the study. After descriptive statistical evaluation, the results were reported in frequency (%). RESULTS: After scanning 2.752 articles, five articles were found that met the research criteria. Examination of full texts of the five identified articles provided no sufficient evidence for research conducted with regard to the use of gene silencing via siRNAs in glioblastoma treatment. CONCLUSION: To be able to evaluate the clinical use of siRNAs, there is an urgent need for in vivo studies and for trials with randomized, controlled, and clinical designs that provide long-term functional outcomes.
dc.identifier.citationKaraarslan, N., Yılmaz, İ., Özbek, H., Çalışkan, T., Topuk, S. Yaşar Şirin, D. ve Ateş, Ö. (2019). Systematic evaluation of promising clinical trials-gene silencing for the treatment of glioblastoma. Turkish Neurosurgery, 29(3), 328-334. https://dx.doi.org/10.5137/1019-5149.JTN.22467-18.3
dc.identifier.doi10.5137/1019-5149.JTN.22467-18.3
dc.identifier.endpage334
dc.identifier.issn1019-5149
dc.identifier.issue3
dc.identifier.scopusqualityQ3
dc.identifier.startpage328
dc.identifier.urihttps://dx.doi.org/10.5137/1019-5149.JTN.22467-18.3
dc.identifier.urihttps://hdl.handle.net/20.500.12511/4008
dc.identifier.volume29
dc.identifier.wosqualityQ4
dc.indekslendigikaynakWeb of Science
dc.indekslendigikaynakScopus
dc.indekslendigikaynakTR-Dizin
dc.indekslendigikaynakPubMed
dc.language.isoen
dc.publisherTurkish Neurosurgical Society
dc.relation.ispartofTurkish Neurosurgeryen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanı
dc.rightsinfo:eu-repo/semantics/openAccess
dc.subjectBrain Tumor
dc.subjectGlioblastoma
dc.subjectPosttranscriptional Gene Silencing
dc.subjectSirna Vector
dc.titleSystematic evaluation of promising clinical trials-gene silencing for the treatment of glioblastoma
dc.typeArticle

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