Synthesis of novel 3, 5, 6-trisubstituted triazine derivatives and their biological activity evaluation as potential antitumor and anti-inflammatory agents

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dc.authorid0000-0002-5976-676X
dc.contributor.authorYurttaş, Leyla
dc.contributor.authorŞahin, Zafer
dc.contributor.authorÇiftçi Akalın, Gülşen
dc.contributor.authorTemel Edip, Halide
dc.contributor.authorDemirayak, Şeref
dc.date.accessioned10.07.201910:49:13
dc.date.accessioned2019-07-10T19:36:15Z
dc.date.available10.07.201910:49:14
dc.date.available2019-07-10T19:36:15Z
dc.date.issued2016
dc.departmentİstanbul Medipol Üniversitesi, Eczacılık Fakültesi, Eczacılık Meslek Bilimleri Bölümü, Farmasötik Kimya Ana Bilim Dalı
dc.description.abstractIn this study, new 3, 5, 6-trisubstituted 1, 2, 4-triazine derivatives (1-9) were synthesized and their structures were determined by using NMR, IR and Mass spectroscopic methods. In vitro antitumor activities against MCF-7 breast adenocarcinoma and C6 rat glioma cell lines were evaluated via MTT colorimetric assay. Among the compounds, compound 4 (IC50=21.0 µg/mL) was found as the most active one against C6 cell line, whereas compound 5 (IC50=9.5 µg/mL) was found the most potent compound against MCF-7 cell line and both of compounds had higher activity than cisplatin in their line. Furthermore, IC50 value of compound 6 was found as 26.0 µg/mL against C6 which was very close to cisplatin potency (IC50=23.5 µg/mL). Besides, all compounds were tested to determine their lipoxygenase (LOX) inhibitory activity. Compounds 1 and 6 showed LOX inhibition with percentages of 43.35% and 38.79% at 100 µg/mL concentration, respectively. The obtained results on cell lines inspire to synthesise new and more potent molecules compounds as anticancer agents.
dc.identifier.citationYurttaş, L., Şahin, Z., Çiftçi Akalın, G., Temel Edip, H. ve Demirayak, Ş. (2016). Synthesis of novel 3, 5, 6-trisubstituted triazine derivatives and their biological activity evaluation as potential antitumor and anti-inflammatory agents. Acta Pharmaceutica Sciencia, 54(1), 83-92. https://dx.doi.org/10.23893/1307-2080.APS.0547
dc.identifier.doi10.23893/1307-2080.APS.0547
dc.identifier.endpage92
dc.identifier.issn1307-2080
dc.identifier.issue1
dc.identifier.scopusqualityN/A
dc.identifier.startpage83
dc.identifier.urihttps://hdl.handle.net/20.500.12511/1107
dc.identifier.urihttps://dx.doi.org/10.23893/1307-2080.APS.0547
dc.identifier.volume54
dc.indekslendigikaynakScopus
dc.language.isoen
dc.publisherUniversity of Istanbul
dc.relation.ispartofActa Pharmaceutica Scienciaen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanı
dc.rightsinfo:eu-repo/semantics/openAccess
dc.subjectAntitumor
dc.subjectCytotoxicity
dc.subjectLipooxygenase (LOX) Inhibition
dc.subjectTriazine
dc.titleSynthesis of novel 3, 5, 6-trisubstituted triazine derivatives and their biological activity evaluation as potential antitumor and anti-inflammatory agents
dc.typeArticle

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