Synthesis of 2-[4,5-dimethyl-1-(phenylamino)-1H-imidazol-2-ylthio]-N-(thiazole-2-yl)acetamide derivatives and their anticancer activities

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dc.contributor.authorDuran, Murat
dc.contributor.authorDemirayak, Şeref
dc.date.accessioned10.07.201910:49:13
dc.date.accessioned2019-07-10T20:01:45Z
dc.date.available10.07.201910:49:13
dc.date.available2019-07-10T20:01:45Z
dc.date.issued2013
dc.departmentİstanbul Medipol Üniversitesi, Eczacılık Fakültesi, Eczacılık Meslek Bilimleri Bölümü, Farmasötik Kimya Ana Bilim Dalı
dc.descriptionWOS: 000322181300007
dc.description.abstractIn this work, 2-(4,5-dimethyl-1-(phenylamino)-1H-imidazol-2-ylthio)-N-(thiazol-2-yl) acetamide derivatives were synthesized by reacting 4,5-dimethyl-1-(phenylamino)-1H-imidazole-2(3H)-thione derivatives with some 2-chloro-N-(thiazol-2-yl)acetamide compounds. The structure of synthesized compounds was confirmed by IR, H-1 NMR, and mass spectra. Anticancer activities of the compounds selected by the National Cancer Institute were investigated by testing against a panel of 60 different human tumor cell lines derived from nine neoplastic cancer types. Compounds 7, 13, and 23 exhibited reasonable anticancer activity against the screened cancer types with relatively low GI(50) values. The compounds showed high activity against melanoma-type cell lines.
dc.description.sponsorshipEskisehir Osmangazi Universityen_US
dc.description.sponsorshipThe authors would like to thank Eskisehir Osmangazi University for support and the National Cancer Institute (NCI), Bethesda, MD, USA, for in vitro screening of the compounds in human cancer cell lines.en_US
dc.identifier.citationDuran, M. ve Demirayak, Ş. (2013). Synthesis of 2-[4,5-dimethyl-1-(phenylamino)-1H-imidazol-2-ylthio]-N-(thiazole-2-yl)acetamide derivatives and their anticancer activities. Medıcınal Chemistry Research, 22(9), 4110-4124. https://dx.doi.org/10.1007/s00044-012-0411-5
dc.identifier.doi10.1007/s00044-012-0411-5
dc.identifier.endpage4124
dc.identifier.issn1054-2523
dc.identifier.issue9
dc.identifier.scopusqualityQ2
dc.identifier.startpage4110
dc.identifier.urihttps://dx.doi.org/10.1007/s00044-012-0411-5
dc.identifier.urihttps://hdl.handle.net/20.500.12511/3428
dc.identifier.volume22
dc.identifier.wosqualityQ4
dc.indekslendigikaynakWeb of Science
dc.indekslendigikaynakScopus
dc.language.isoen
dc.publisherSpringer Birkhauser
dc.relation.ispartofMedıcınal Chemistry Researchen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanı
dc.rightsinfo:eu-repo/semantics/embargoedAccess
dc.subjectImidazole
dc.subjectThiazole
dc.subjectAnticancer
dc.subjectMelanoma
dc.subjectAcetamide
dc.titleSynthesis of 2-[4,5-dimethyl-1-(phenylamino)-1H-imidazol-2-ylthio]-N-(thiazole-2-yl)acetamide derivatives and their anticancer activities
dc.typeArticle

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