Ophthalmic applications of SLN and NLC

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dc.authorid0000-0002-3210-3747
dc.contributor.authorÜstündağ Okur, Neslihan
dc.contributor.authorHoman Gökçe, Evren
dc.date.accessioned2020-07-16T09:19:52Z
dc.date.available2020-07-16T09:19:52Z
dc.date.issued2017
dc.departmentİstanbul Medipol Üniversitesi, Eczacılık Fakültesi, Eczacılık Teknolojisi Bölümü, Farmasötik Teknoloji Ana Bilim Dalı
dc.description.abstractBackground: The eyes are among the most readily accessible organs in terms of location in the body, yet drug delivery to eye tissues is particularly problematic. The anatomy, physiology and biochemistry of the eye limit the ophthalmic delivery of drugs. Numerous strategies in ophthalmic drug delivery have been made to expand the bioavailability and to prolong the remaining time of drugs treated topically to eye.Methods: Designing a novel delivery vehicles that can proficiently target the diseased eye tissue, generate high drug levels, and keep sustained and effective concentrations with no or minimum side effects is the main concentration of present examination. One of the encouraging approaches currently is the use of lipidic nanoparticle vehicles categorized by a submicron-meter dimension. Due to their properties and numerous advantages, solid lipid nanoparticles and nanostructure lipid carriers are promising systems for ocular drug delivery.Conclusion: The focus of this review is on the recent developments in ophthalmic lipid nanoparticles, the rationale for their use, drug loaded SLNs and NLCs, and the characteristic advantages, limitations of this system and recent studies.
dc.identifier.citationÜstündağ Okur, N. ve Homan Gökçe, E. (2017). Ophthalmic applications of SLN and NLC. Current Pharmaceutical Design, 23(43), 6676-6683. https://dx.doi.org/10.2174/1381612823666171115113101
dc.identifier.doi10.2174/1381612823666171115113101
dc.identifier.endpage6683
dc.identifier.issn1381-6128
dc.identifier.issn1873-4286
dc.identifier.issue43
dc.identifier.scopusqualityQ2
dc.identifier.startpage6676
dc.identifier.urihttps://dx.doi.org/10.2174/1381612823666171115113101
dc.identifier.urihttps://hdl.handle.net/20.500.12511/5512
dc.identifier.volume23
dc.identifier.wosqualityQ3
dc.indekslendigikaynakWeb of Science
dc.indekslendigikaynakScopus
dc.indekslendigikaynakPubMed
dc.language.isoen
dc.publisherBentham Science Publishers Ltd.
dc.relation.ispartofCurrent Pharmaceutical Designen_US
dc.relation.publicationcategoryDiğer
dc.rightsinfo:eu-repo/semantics/closedAccess
dc.subjectOcular Drug Delivery
dc.subjectNanotechnology
dc.subjectNanocarriers
dc.subjectLipid Nanoparticles
dc.subjectSLN
dc.subjectNLC
dc.titleOphthalmic applications of SLN and NLC
dc.typeReview Article

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