Toward a personalized medicine in wake-up stroke?

Ischemic stroke (IS), especially wake-up stroke, is reported to occur with a maximal peak in the morning hoursand usually associated with worse clinical outcome [1-3].Many proposed mechanisms are reported to be responsiblefor the impaired clinical outcomes in IS patients, includinghemostatic and hemodynamic factors. Despite this fact, recent reports have pointed out that circadian pattern independently affects the outcome of IS that persists even whencontrolling for vascular risk factors and different treatmentmodalities (such as anti-platelet or anticoagulant treatment)