Investigation of therapeutic effects in the wound healing of chitosan/pGM-CSF complexes

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dc.authorid0000-0002-1693-9579
dc.contributor.authorŞalva, Emine
dc.contributor.authorAlan, Saadet
dc.contributor.authorKarakoyun, Berna
dc.contributor.authorÇakalağaoğlu, Fulya
dc.contributor.authorÖzbaş, Suna
dc.contributor.authorAkbuğa, Jülide
dc.date.accessioned2022-07-28T13:37:27Z
dc.date.available2022-07-28T13:37:27Z
dc.date.issued2022
dc.departmentİstanbul Medipol Üniversitesi, Eczacılık Fakültesi, Eczacılık Teknolojisi Bölümü, Farmasötik Teknoloji Ana Bilim Dalı
dc.description.abstractGranulocyte macrophage colony-stimulating factor (GM-CSF) has been shown to promote the growth, proliferation, and migration of endothelial and keratinocyte cells. Chitosan has been widely used as a biopolymer in wound-healing studies. The aim of this study was to investigate the in vitro proliferative effects of chitosan/pGM-CSF complexes as well as the therapeutic role of the complexes in an in vivo rat wound model. The effect of complexes on cell proliferation and migration was examined. Wounds were made in Wistar-albino rats, and examined histopathologically. The cell proliferation and migration were increased weight ratio- and time-dependently in HaCaT and NIH-3T3 cell lines. Wound healing was significantly accelerated in rats treated with the complexes. These results showed that the delivery of pGM-CSF using chitosan complexes could play an accelerating role in the cell proliferation, migration, and wound-healing process.
dc.identifier.citationŞalva, E., Alan, S., Karakoyun, B., Çakalağaoğlu, F., Özbaş, S. ve Akbuğa, J. (2022). Investigation of therapeutic effects in the wound healing of chitosan/pGM-CSF complexes. Brazilian Journal of Pharmaceutical Sciences, 58. https://doi.org/10.1590/s2175-97902022e19668
dc.identifier.doi10.1590/s2175-97902022e19668
dc.identifier.issn1984-8250
dc.identifier.issn2175-9790
dc.identifier.scopus2-s2.0-85134212710
dc.identifier.scopusqualityQ2
dc.identifier.urihttps://doi.org/10.1590/s2175-97902022e19668
dc.identifier.urihttps://hdl.handle.net/20.500.12511/9616
dc.identifier.volume58
dc.identifier.wos000826298400001en_US
dc.identifier.wosqualityQ4
dc.indekslendigikaynakWeb of Science
dc.indekslendigikaynakScopus
dc.institutionauthorAkbuğa, Jülide
dc.language.isoen
dc.publisherUniversidade de São Paulo
dc.relation.ispartofBrazilian Journal of Pharmaceutical Sciencesen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanı
dc.relation.tubitakinfo:eu-repo/grantAgreement/TUBITAK/SOBAG/SBAGHD-155
dc.rightsAttribution 4.0 International*
dc.rightsinfo:eu-repo/semantics/openAccess
dc.rights.urihttps://creativecommons.org/licenses/by/4.0/*
dc.subjectWound Healing
dc.subjectChitosan
dc.subjectpGM-CSF
dc.subjectComplexes
dc.titleInvestigation of therapeutic effects in the wound healing of chitosan/pGM-CSF complexes
dc.typeArticle

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