Umbilical cord mesenchymal stem cells and lung cancer: We should be hopeful or hopeless?

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dc.authorid0000-0001-6428-0791
dc.contributor.authorArefnezhad, Reza
dc.contributor.authorHelfi, Maryam
dc.contributor.authorOkhravijouybari, Rana
dc.contributor.authorGoleij, Pouya
dc.contributor.authorSargolzaeimoghaddam, Maral
dc.contributor.authorMohammadi, Hanieh
dc.contributor.authorMahdaviyan, Naeemeh
dc.contributor.authorFatemian, Hossein
dc.contributor.authorSarg, Arya
dc.contributor.authorJahani, Saleheh
dc.contributor.authorRezaei Tazangi, Fatemeh
dc.contributor.authorNazari, Ahmad
dc.date.accessioned2024-06-06T06:28:59Z
dc.date.available2024-06-06T06:28:59Z
dc.date.issued2024
dc.departmentİstanbul Medipol Üniversitesi, Tıp Fakültesi
dc.description.abstractLung cancer (LC) is one of the leading causes of cancer-caused death that possesses a poor prognosis and low survival rate worldwide. In general, LC is classified into small-cell (SCLC) and non-small-cell carcinoma (NSCLC) (involving 80% of patients). Although chemotherapy, radiotherapy, surgery, and molecular-targeted therapy are considered standard approaches for LC treatment, these options have low success with detrimental effects on the life quality of patients. Ergo, recommending treatment with maximum effectiveness and minimum side effects for LC patients has been a substantial challenge for researchers and clinicians in the present era. Recently, mesenchymal stem cells (MSCs)-based strategies have sparked much interest in preventing or treating numerous illnesses. These multipotent stem cells can be isolated from diverse sources, such as umbilical cord, bone marrow, and adipose tissue. Among these sources, umbilical cord mesenchymal stem cells (UC-MSCs) have been in the spotlight of MSCs-based therapies thanks to their considerable advantages, such as high proliferation ability, low immune reactions and tumorigenesis, and easiness in collection and isolation. Some experimental studies have investigated the functionality of intact UC-MSCs and extracellular vesicles, exosomes, and conditioned medium derived from UC-MSCs, as well as genetically engineered UC-MSCs. In this review, we aimed to highlight the influences of these UMSCs-based methods in LC treatment with cellular and molecular insights.
dc.identifier.citationArefnezhad, R., Helfi, M., Okhravijouybari, R., Goleij, P., Sargolzaeimoghaddam, M., Mohammadi, H. ... Nazari, A. (2024). Umbilical cord mesenchymal stem cells and lung cancer: We should be hopeful or hopeless?. Tissue and Cell, 88. http://dx.doi.org/10.1016/j.tice.2024.102410
dc.identifier.doi10.1016/j.tice.2024.102410
dc.identifier.issn0040-8166
dc.identifier.pmid38772275
dc.identifier.scopus2-s2.0-85193472052
dc.identifier.scopusqualityQ2
dc.identifier.urihttp://dx.doi.org/10.1016/j.tice.2024.102410
dc.identifier.urihttps://hdl.handle.net/20.500.12511/12577
dc.identifier.volume88
dc.identifier.wosWOS:001294615900001en_US
dc.identifier.wosqualityQ1en_US
dc.indekslendigikaynakScopus
dc.indekslendigikaynakPubMed
dc.institutionauthorSargolzaeimoghaddam, Maral
dc.institutionauthorSarg, Arya
dc.language.isoen
dc.relation.ispartofTissue and Cellen_US
dc.relation.publicationcategoryDiÄŸer
dc.rightsinfo:eu-repo/semantics/openAccess
dc.subjectLung Cancer
dc.subjectMesenchymal Stem Cells
dc.subjectUmbilical Cord
dc.titleUmbilical cord mesenchymal stem cells and lung cancer: We should be hopeful or hopeless?
dc.typeOther

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