Importance and review of drug metabolite synthesis

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dc.authorid0000-0002-4144-6952
dc.contributor.authorŞahin, Zafer
dc.contributor.authorOmurtag Özgen, Pınar Sinem
dc.contributor.authorRollas, Sevim
dc.date.accessioned2024-01-12T11:38:30Z
dc.date.available2024-01-12T11:38:30Z
dc.date.issued2023
dc.departmentİstanbul Medipol Üniversitesi, Eczacılık Fakültesi, Eczacılık Meslek Bilimleri Bölümü, Farmasötik Kimya Ana Bilim Dalı
dc.description.abstractPhase I and Phase II metabolic reactions are involved in the pharmacokinetic properties of drugs after administration. These reactions mainly aim to make drugs more polar and eliminate them safely. However, some of these metabolites have the potential to exhibit a toxicological effect. Industry and/or academia have to consider these metabolites in terms of their pharmacodynamic and pharmacokinetic properties. These metabolites are not only residual intermediates from the synthetic process of the main drug but also unique structures produced by metabolic enzymes in the human organism. Thus, metabolite synthesis by synthetic or semi-synthetic methods is a key feature in the pharmaceutical industry. In this review, synthetic methods of the metabolites from all known metabolic pathways are reviewed from the literature. It was observed that both synthetic and semi-synthetic methods require more attention as they are as important and complex as drug synthesis. Moreover, it showed that there was much more research available for Phase I than Phase II in the literature.
dc.identifier.citationŞahin, Z., Omurtag Özgen, P. S. ve Rollas, S. (2023). Importance and review of drug metabolite synthesis. İstanbul Journal of Pharmacy, 53(2), 251-269. https://dx.doi.org/10.26650/IstanbulJPharm.2023.1033045
dc.identifier.doi10.26650/IstanbulJPharm.2023.1033045
dc.identifier.endpage269
dc.identifier.issn2587-2087
dc.identifier.issue2
dc.identifier.startpage251
dc.identifier.urihttps://dx.doi.org/10.26650/IstanbulJPharm.2023.1033045
dc.identifier.urihttps://hdl.handle.net/20.500.12511/12133
dc.identifier.volume53
dc.identifier.wos001110261800009en_US
dc.identifier.wosqualityN/A
dc.indekslendigikaynakWeb of Science
dc.institutionauthorRollas, Sevim
dc.language.isoen
dc.publisherIstanbul University
dc.relation.ispartofİstanbul Journal of Pharmacyen_US
dc.relation.publicationcategoryDiğer
dc.rightsinfo:eu-repo/semantics/openAccess
dc.subjectDrug Metabolite
dc.subjectMetabolism
dc.subjectSynthesis
dc.subjectOxidation
dc.subjectPhase I
dc.subjectPhase II
dc.titleImportance and review of drug metabolite synthesis
dc.typeReview Article

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