Does MESNA application make sense in chronic otitis media surgery?

We have read with pleasure the article by Kalcioglu MT. et al. [1] which presents very important clinical observations. We would like to make some comments on this problem, basing on our experience and the literature review. MESNA (sodium 2-mercapto-ethane sulphonate) is a synthetic sulfur compound that produces mucolysis by disrupting disulfide bonds of the mucus polypeptide chain. MESNA can be used during ear surgeries (cholesteatoma or atelectasis), to make the dissection of keratinocyte layers [2,3]. But a question remains over the possible mechanism of action of MESNA in chronic otitis media. Therefore, we would like to share our opinion in this subject.