In vitro ACE2 enzyme inhibitory activity evaluation of different salvia essential oils

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dc.authorid0000-0002-3412-0807
dc.authorid0000-0003-1896-2729
dc.contributor.authorKaradağ, Ayşe Esra
dc.contributor.authorBiltekin, Sevde Nur
dc.contributor.authorDemirci, Betül
dc.contributor.authorDemirci, Fatih
dc.date.accessioned2022-06-06T10:01:04Z
dc.date.available2022-06-06T10:01:04Z
dc.date.issued2022
dc.departmentİstanbul Medipol Üniversitesi, Eczacılık Fakültesi, Eczacılık Meslek Bilimleri Bölümü, Farmakognozi Ana Bilim Dalı
dc.departmentİstanbul Medipol Üniversitesi, Eczacılık Fakültesi, Temel Eczacılık Bilimleri Bölümü, Farmasötik Mikrobiyoloji Ana Bilim Dalı
dc.description.abstractIn this present study, commertially available Salvia triloba L., S.officinalis L., and S. sclarea L. essential oils were evaluated for their in vitro angiotensin converting enzyme 2 (ACE2) inhibitory activity. The Salvia essential oils compositions were confirmed both by GC-FID and GC/MS. Main components of the S. triloba essential oil was characterized as 1,8-cineole (22.8%), camphor (17.2%), ?-thujone (15.2 %), ?-caryophyllene (11.4 %), and ?-humulene (3%). Major constiutents were identified as ?-thujone (28.5 %), camphor (20.6 %), 1,8-cineole (10.9%), ?-humulene (5%), and camphene (4.9 %) in S. officinalis essential oil. Whereas, linalylacetate (56.8 %), linalool (21.1%), ?-terpineol (6.1%), geraniol (5%), and ?-caryophyllene (3.4%) were the major components of S. sclarea essential oil. The essential oils were evaluated using a fluorometric multiplate based enzyme inhibition kit, where the ACE2 inhi-bitions of S. triloba, S. officinalis, and S. sclarea essential oils were 50.1%, 60.5%, and 72.1% at a concentration of 20 µg/mL, respectively. As a result, further tests of Salvia essential oils supported by in vivo studies may have antiviral potential ap-plications against coronaviruses due to ACE2 enzyme inhibitions.
dc.identifier.citationKaradağ, A. E., Biltekin, S. N., Demirci, B. ve Demirci, F. (2022). In vitro ACE2 enzyme inhibitory activity evaluation of different salvia essential oils. Acta Pharmaceutica Sciencia, 60(2), 117-124. https://doi.org/10.23893/1307-2080.APS.6008
dc.identifier.doi10.23893/1307-2080.APS.6008
dc.identifier.endpage124
dc.identifier.issn1307-2080
dc.identifier.issue2
dc.identifier.scopus2-s2.0-85130165186
dc.identifier.scopusqualityQ3
dc.identifier.startpage117
dc.identifier.urihttps://doi.org/10.23893/1307-2080.APS.6008
dc.identifier.urihttps://hdl.handle.net/20.500.12511/9508
dc.identifier.volume60
dc.indekslendigikaynakScopus
dc.institutionauthorKaradağ, Ayşe Esra
dc.institutionauthorBiltekin, Sevde Nur
dc.language.isoen
dc.publisherIstanbul Medipol University
dc.relation.ispartofActa Pharmaceutica Scienciaen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanı
dc.rightsinfo:eu-repo/semantics/closedAccess
dc.subjectACE2
dc.subjectCoronavirus
dc.subjectEssential Oil
dc.subjectSalvia
dc.titleIn vitro ACE2 enzyme inhibitory activity evaluation of different salvia essential oils
dc.typeArticle

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