Formulation of microemulsions for dermal delivery of Cephalexin

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dc.authorid0000-0002-3210-3747
dc.authorid0000-0003-2010-4918
dc.contributor.authorÜstündağ Okur, Neslihan
dc.contributor.authorEr, Sevda
dc.contributor.authorÇağlar, Emre Şefik
dc.contributor.authorEkmen, Tarık Ziya
dc.contributor.authorSala, Furkan
dc.date.accessioned10.07.201910:49:13
dc.date.accessioned2019-07-10T19:36:13Z
dc.date.available10.07.201910:49:14
dc.date.available2019-07-10T19:36:13Z
dc.date.issued2017
dc.departmentİstanbul Medipol Üniversitesi, Eczacılık Fakültesi, Eczacılık Teknolojisi Bölümü, Farmasötik Teknoloji Ana Bilim Dalı
dc.description.abstractIntroduction: Cephalexin monohydrate (CEM) is mostly used because of its activity against both the gram-positive and gram-negative microorganisms for infections. Microemulsions offer numerous advantages for dermal delivery of drugs. Objective: The objective of the present study was to prepare novel CEM loaded microemulsions and to characterize formulations, to evaluate their in vitro release profiles and antibacterial activities. Method: CEM loaded formulations [0.02% (w/w)] were characterized according to their droplet size, zeta potential, PDI, pH, electrical conductivity and viscosity. In addition, in vitro drug release studies and antibacterial activity tests were performed. Results: The developed CEM loaded microemulsions (M1 and M2) achieved narrow droplet size distribution (152.75±4.85 and 128.05±9.22), low PDI (0.364±0.05 and 0.489±0.06), suitable pH (5.28-4.84) and conductivity (342±4.472-374±5.477 µS/cm). Zeta potential was measured as 0.209±0.041 and 0.141±0.024 mV. M1CEM showed 100% release at the 7th hour and was provided almost the same zone diameter as CEM solution when evaluated for antibacterial activity. Conclusion: Overall, it was concluded that microemulsions might be beneficial in improving dermal delivery of CEM for the treatment of skin and soft tissue infections.
dc.identifier.citationÜstündağ Okur, N., Er, S., Çağlar, E. Ş., Ekmen, T. Z. ve Sala, F. (2017). Formulation of microemulsions for dermal delivery of Cephalexin. Acta Pharmaceutica Sciencia, 55(4), 27-40. https://dx.doi.org/10.23893/1307-2080.APS.05524
dc.identifier.doi10.23893/1307-2080.APS.05524
dc.identifier.endpage40
dc.identifier.issn1307-2080
dc.identifier.issue4
dc.identifier.scopusqualityQ4
dc.identifier.startpage27
dc.identifier.urihttps://hdl.handle.net/20.500.12511/1097
dc.identifier.urihttps://dx.doi.org/10.23893/1307-2080.APS.05524
dc.identifier.volume55
dc.indekslendigikaynakScopus
dc.language.isoen
dc.publisherUniversity of Istanbul
dc.relation.ispartofActa Pharmaceutica Scienciaen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanı
dc.rightsinfo:eu-repo/semantics/openAccess
dc.subjectAntibacterial Activity
dc.subjectCephalexin
dc.subjectDermal Delivery
dc.subjectIn Vitro Release
dc.subjectMicroemulsion
dc.titleFormulation of microemulsions for dermal delivery of Cephalexin
dc.typeArticle

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